General Oncology Resource Center

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Is Real-World Evidence a Complement to Randomized Clinical Trials?

Use of real-world data has the potential to accelerate drug and device approvals in rare diseases and advance precision medicine initiatives.

Effect of BRCA Mutations on Ovarian Reserve After Chemotherapy

Women with BRCA 1/2 mutations have lower ovarian reserve and experience greater ovarian reserve loss after chemotherapy compared with those who are BRCA wild-type.

Tumor Hypoxia and Papaverine: A New Use for an Old Drug?

Papaverine was found to sensitize tumors in a way that could potentially improve their response to radiation therapy in patients with certain tumor types.

Gene-Delivery Method Generates Immune Checkpoint Antibodies In Vivo

In mice, DNA-encoded plasmids generated sufficient in vivo expression of immune checkpoint antibody CTLA-4; DMabs may one day rival traditional mAbs.

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