General Oncology

Finding Clinical Trials in Cancer

Finding Clinical Trials in Cancer

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This fact sheet describes patient-directed strategies for finding clinical trials.

Managing Immune-Related Adverse Events

Managing Immune-Related Adverse Events

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An overview of the potential immune-related adverse events that can arise from treatment with checkpoint inhibitors.

Cancer Chemotherapeutics in Rheumatoid Arthritis: A Complex Connection

Cancer Chemotherapeutics in Rheumatoid Arthritis: A Complex Connection

Research is still needed to explore the association between cancer chemotherapeutics and rheumatoid arthritis.

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

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More than 90 medical societies have called on the US government to reverse a policy allowing step therapy under Medicare Advantage.

Identifying Gene Variants Involved in Radiotherapy Toxicity Risk: A Q&A With Benjamin Smith, MD

Identifying Gene Variants Involved in Radiotherapy Toxicity Risk: A Q&A With Benjamin Smith, MD

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Genomics could guide the decision about whether a patient should undergo implant reconstruction or autologous tissue-based reconstruction.

Managing Neutropenia

Managing Neutropenia

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Both the chemotherapy regimen selected and therapeutic dose intensity used in treatment factor into the calculation of neutropenia risk.

FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

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There is a push to create innovative adaptive trial designs that include more patients and, subsequently, more generalizable data.

Clues from DNA Repair Mechanisms Could Drive Novel Therapeutic Strategies

Clues from DNA Repair Mechanisms Could Drive Novel Therapeutic Strategies

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Metabolites from the Krebs cycle were found to suppress the DNA-repair pathway required for the preservation of genomic integrity.

Care Coordination Recognized as Biggest Safety Concern in Oncology: Study

Care Coordination Recognized as Biggest Safety Concern in Oncology: Study

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In a recent analysis of VA hospital records, more than half of all oncologic errors and adverse events were attributed to uncoordinated cancer care.

Genetic Testing and Cancer

Genetic Testing and Cancer

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Traditional genetic testing historically included the sequential analysis of single and generally well-described genes involved in heritable cancers.

Bispecific Antibodies in Cancer

Bispecific Antibodies in Cancer

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Interest in these bioengineered antibodies has been rekindled by the striking success seen in the treatment of some cancers with immunotherapies.

Depression as a Side Effect: Exploring a Link Between Certain Cancer Treatments and Mental Health

Depression as a Side Effect: Exploring a Link Between Certain Cancer Treatments and Mental Health

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Researchers are promoting physician and patient awareness about the potential tie between depression and certain therapies.

Paradigm shift in cancer treatment to targeted therapies

Cancer therapy is a continually evolving field, as researchers strive to determine the most effective methods of treating this complex disease.

Psychotherapy and Cancer

Psychotherapy and Cancer

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Some data suggest that psychotherapy may benefit patients with cancer, but higher-quality research is needed.

Is Paraneoplastic Granuloma Annulare Linked to Solid Organ Malignancies?

Is Paraneoplastic Granuloma Annulare Linked to Solid Organ Malignancies?

Recurrence of GA following cancer treatment should signal the possibility of cancer recurrence.

TNFi Not Linked to Increased Risk for Cancer Recurrence in Rheumatoid Arthritis

TNFi Not Linked to Increased Risk for Cancer Recurrence in Rheumatoid Arthritis

TNFi treatment is not associated with increased risk for cancer recurrence in patients with rheumatoid arthritis

Study Reveals Scope of Genomic Variation Within Cancer Cell Lines

Study Reveals Scope of Genomic Variation Within Cancer Cell Lines

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Tumor cell lines derived from single cells and curated at different reference labs have quietly evolved in vitro, accumulating distinct genomic aberrations.

Polypharmacy and Cancer

Polypharmacy and Cancer

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The effect of polypharmacy and noncancer mortality on patient survival and other outcomes in cancer varies by study.

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

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Approximately half of patients with advanced cancer who are enrolled in phase 1 clinical trials do not know the ultimate goal of the study.

Financial Toxicity and Cancer

Financial Toxicity and Cancer

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Though it is clear that cancer is associated with an extreme financial burden, the extent of the burden varies widely.

Dietary Nitrates/Nitrites and Cancer

Dietary Nitrates/Nitrites and Cancer

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There is concern that added nitrates and nitrites are associated with an increased risk of cancer, but epidemiologic data have been inconclusive thus far.

Do Men Benefit More From Immune Checkpoint Inhibition?

Do Men Benefit More From Immune Checkpoint Inhibition?

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A meta-analysis of 20 randomized clinical trials found that men may infer a greater benefit from immune checkpoint inhibition.

Persistent Cancer Screening Gaps Revealed in New CDC Report

Persistent Cancer Screening Gaps Revealed in New CDC Report

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From 2000 to 2015 screening for breast, cervical, and prostate cancers decreased significantly, whereas screening for colorectal cancer increased significantly.

Population-Level Reductions in Alcohol, Tobacco Use May Reduce Overall Cancer Mortality

Population-Level Reductions in Alcohol, Tobacco Use May Reduce Overall Cancer Mortality

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There has been little historical evidence to show whether modifying per capita use of alcohol and/or tobacco could affect the cancer mortality rate.

Cancer Mortality Rates Differ Across Racial and Ethnic Subgroups

Cancer Mortality Rates Differ Across Racial and Ethnic Subgroups

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The subtle differences within subsets of populations could tell researchers more about how some cancers affect distinct racial or ethnic populations across a heterogeneous group of minorities.

Exercise and Cancer

Exercise and Cancer

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The mechanisms that drive this benefit are not well-understood, and it is believed that the benefit is not just a result of reducing risk factors such as body weight.

Triclosan and Cancer Risk: Is There a Link?

Triclosan and Cancer Risk: Is There a Link?

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Some studies suggest triclosan could have oncogenic properties, but more research is needed to confirm a causal link.

Drugs Approved Under the Breakthrough Therapy Pathway Lack Basic Features of High-Quality Trials

Drugs Approved Under the Breakthrough Therapy Pathway Lack Basic Features of High-Quality Trials

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Close postmarketing monitoring will be especially crucial for drugs approved with a breakthrough therapy designation, as many of them were given a pass on the basis of a single pivotal trial.

CRISPR Method of Gene Editing Creates Massive Genetic Reshuffling

CRISPR Method of Gene Editing Creates Massive Genetic Reshuffling

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Drug developers relying on CRISPR-Cas9 platforms for the creation of gene therapies saw their shares slide when it was revealed that the technique may inadvertently cause disruptions of larger chunks of DNA than previously thought.

FDA-Approved Breast Cancer Drug Treatments

Treatment chart with usual dosage, strength, and formulation of FDA approved medications for breast cancer.

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