Genetics

NSCLC: Genetic Mutations May Determine Likelihood of Metastasis at Diagnosis

NSCLC: Genetic Mutations May Determine Likelihood of Metastasis at Diagnosis

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Compared with ALK¬-positive patients, participants with ROS1 rearrangements were less likely to present with extrathoracic and brain metastases.

CAR T Cell Therapy for Acute Lymphoblastic Leukemia: An Evolutionary Perspective

CAR T Cell Therapy for Acute Lymphoblastic Leukemia: An Evolutionary Perspective

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Enthusiasm for the CAR T cell approach may redirect rather than augment other possibly safer, more effective, evolutionarily informed approaches to cancer therapy.

Q&A With Scott Roberts, PhD: Direct-to-Consumer Cancer Gene Testing

Q&A With Scott Roberts, PhD: Direct-to-Consumer Cancer Gene Testing

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In this question-and-answer session, Cancer Therapy Advisor asked Dr Roberts about direct-to-consumer genomic testing for cancer risk.

GATA2 in Prostate Cancer: A Promising Biomarker

GATA2 in Prostate Cancer: A Promising Biomarker

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The pioneer transcription factor GATA2 has been implicated in prostate tumorigenesis, tumor aggressiveness, treatment resistance, and metastasis, making it a promising biomarker.

Looking to the Genome for Prostate Cancer Biomarkers

Looking to the Genome for Prostate Cancer Biomarkers

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Researchers are trying to develop prostate cancer biomarkers that can predict treatment effects, to spare patients toxicities associated with unhelpful regimens.

Research Suggests That Multiple Myeloma Is Heritable

Research Suggests That Multiple Myeloma Is Heritable

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Oncologists may be on the path towards elucidating clinically translatable etiologies of MM.

Patterns in PI3K Signaling Pathway Aberrations Evaluated

Patterns in PI3K Signaling Pathway Aberrations Evaluated

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Researchers argue that combination therapies targeting both mutations in the PI3K pathway and HER2 or hormone receptor overexpression should be evaluated across cancer types.

NCI Launches $12m Study on Breast Cancer Genetics

NCI Launches $12m Study on Breast Cancer Genetics

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The National Cancer Institute (NCI) has provided a 12 million dollar grant to fund a collaborative study on breast cancer genetics in African American women.

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