Genitourinary Cancer

Men With Prostate Cancer Willing to Accept Worse Survival Odds to Improve QoL

Men With Prostate Cancer Willing to Accept Worse Survival Odds to Improve QoL

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Trade-offs should be carefully considered, as data have indicated that many QoL factors eventually even out.

Gender-Based Differences in Chemotherapy: Efficacy and Safety

Gender-Based Differences in Chemotherapy: Efficacy and Safety

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Women and men were found to react differently to treatment with chemotherapy, although gender-based survival differences were not observed.

Moving Targets: Off-Label Prescribing of Targeted Therapies

Moving Targets: Off-Label Prescribing of Targeted Therapies

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By way of the TAPUR study, researchers are attempting to evaluate the activity of targeted therapies when they are used in an off-label setting.

The Patient Behind the EHR: Oncologists Only See Half the Picture

The Patient Behind the EHR: Oncologists Only See Half the Picture

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Dr Vorobiof discusses the importance patient factors that can be missed via standard data collection methods for patients with cancer.

Microwave Ablation for Early-Stage Renal Tumors

Microwave Ablation for Early-Stage Renal Tumors

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Image-guided microwave ablation of early-stage renal tumors shows promise but a new retrospective study from the Mayo Clinic found some cases of major bleeding.

Prognostic Model for Survival in Metastatic Prostate Cancer

Prognostic Model for Survival in Metastatic Prostate Cancer

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Utilizing data from the PREVAIL dataset, researchers developed mathematical models that can provide prognostic information for men being treated with enzalutamide for chemotherapy-naïve metastatic castration-resistant prostate cancer.

Anticarcinogenic Activity of Fish Oil Explored in Study

Anticarcinogenic Activity of Fish Oil Explored in Study

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Omega-3 fatty acids found in fish oil act through a host receptor, GPR120, to confer anti-prostate cancer effects. Additional studies are underway.

Radiotherapy Did Not Improve Survival in All Patients With Metastatic Prostate Cancer

Radiotherapy Did Not Improve Survival in All Patients With Metastatic Prostate Cancer

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Radiotherapy may improve survival among men with low metastatic burden, but not in all patients with metastatic prostate cancer.

High Distress in Patients With Renal Cell Carcinoma, Call for Better Psychosocial Screening

High Distress in Patients With Renal Cell Carcinoma, Call for Better Psychosocial Screening

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A high prevalence of patients with renal cell carcinoma reported distress, highlighting the need for better psychosocial screening of patients.

MicroRNA Signature in Urine May Predict Presence of Bladder Cancer

MicroRNA Signature in Urine May Predict Presence of Bladder Cancer

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Researchers found a microRNA signature in urine that can predict the presence of bladder cancer, advancing the idea of a noninvasive diagnostic test.

Who Determines What 'Value' Looks Like in Value-Based Cancer Care?

Who Determines What 'Value' Looks Like in Value-Based Cancer Care?

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Evaluation of patient-reported outcomes (PROs) is an important component of measuring quality in cancer care.

Reclassification of Variants of Uncertain Significance: A Q&A With Theodora Ross MD, PhD

Reclassification of Variants of Uncertain Significance: A Q&A With Theodora Ross MD, PhD

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Dr Ross described how genomic reports may need to be updated to account for new insights into a variant's role in cancer.

Cabozantinib Effective Regardless of PD-L1 Expression in RCC

Cabozantinib Effective Regardless of PD-L1 Expression in RCC

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PD-L1 tumor expression was found not to be a predictive biomarker for cabozantinib efficacy in mRCC.

Combination Abiraterone Acetate, Radium-223 Not Recommended in CRPC With Bone Mets

Combination Abiraterone Acetate, Radium-223 Not Recommended in CRPC With Bone Mets

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The regimen did not improve survival and increased bone fractures.

Using ctDNA to Predict Cancer Recurrence and Guide Therapy Selection

Using ctDNA to Predict Cancer Recurrence and Guide Therapy Selection

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A ctDNA testing method has the capability to predict cancer recurrence, which could help guide therapy selections and uncover new drug development opportunities.

Apalutamide Does Not Diminish Quality of Life in Nonmetastatic Castration-Resistant Prostate Cancer

Apalutamide Does Not Diminish Quality of Life in Nonmetastatic Castration-Resistant Prostate Cancer

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Findings from the SPARTAN trial show that HRQoL is not diminished by adding apalutamide to androgen deprivation therapy in men with asymptomatic, nonmetastatic CRPC.

Role of miR-125a-5p Clarified in Bladder Cancer

Role of miR-125a-5p Clarified in Bladder Cancer

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Researchers clarified the role of miR-125a-5p in bladder cancer, showing that it inhibits bladder cancer progression by targeting oncogene FUT4.

Bladder Cancer Clinical Features Linked to <i>EGFR</i> and </i>HER2</i> Expression

Bladder Cancer Clinical Features Linked to EGFR and HER2 Expression

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A retrospective study found EGFR and HER2 overexpression associated with clinical features, such as tumor stage and tumor recurrence, in bladder cancer tissue.

Bladder Cancer Risk Higher With Radiation Therapy for Prostate Cancer

Bladder Cancer Risk Higher With Radiation Therapy for Prostate Cancer

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In a recently published study, external beam radiation therapy for localized prostate cancer was associated with a 35% increased risk of bladder cancer compared with radical prostatectomy.

Comparison of Multimodal Approaches in High-Risk Prostate Cancer

Comparison of Multimodal Approaches in High-Risk Prostate Cancer

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Men treated with radical prostatectomy plus radiotherapy for locally or regionally advanced prostate cancer had improved survival but worse adverse events.

Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?

Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?

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In clinical practice, most physicians and nurse practitioners do not feel comfortable enough with their medical knowledge of cannabis to offer it to patients.

Robotic Tumor Enucleation Appears Safe for Sporadic Renal Cell Carcinoma

Robotic Tumor Enucleation Appears Safe for Sporadic Renal Cell Carcinoma

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Long-term oncologic outcomes of patients with sporadic RCC who underwent robotic tumor enucleation suggest the procedure is safe.

Fall of Star Cancer Researcher Brings Broader Picture Into View

Fall of Star Cancer Researcher Brings Broader Picture Into View

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Dr José Baselga failed to disclose his financial ties to pharmaceutical companies in top-tier journals, causing many to question whether conflicts of interest are being properly reported.

Bladder Cancer Surveillance Not Aligned With Risk: Study of VA Facilities

Bladder Cancer Surveillance Not Aligned With Risk: Study of VA Facilities

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Patients at VA facilities with high-risk early-stage bladder cancer tend to have cystoscopic surveillance at frequencies similar to those with low-risk disease.

Certain Muscle-Invasive Bladder Cancer Subtypes Do Not Respond to Neoadjuvant Cisplatin

Certain Muscle-Invasive Bladder Cancer Subtypes Do Not Respond to Neoadjuvant Cisplatin

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Treatment with NAC did not transform the prevailing subtype in bladder cancer — instead, shifts in cancer subtype were attributed to tumor plasticity.

High Mutation Load Seen in the High-Risk Prostate Tumors of African Men

High Mutation Load Seen in the High-Risk Prostate Tumors of African Men

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Differences in TMB between African and European patients show that "racial mutational disparity is not a technical or computational artifact," according to authors.

The Identification of a Potential Early Plasma Biomarker for Kidney Cancer

The Identification of a Potential Early Plasma Biomarker for Kidney Cancer

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Researchers found that doubling in KIM-1 plasma concentrations was associated with an increased risk of developing RCC and poorer survival.

Prostate Cancer Drug Resistance Mediated by Epigenetic Changes

Prostate Cancer Drug Resistance Mediated by Epigenetic Changes

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Epigenetic changes in the tumor microenvironment may explain why prostate cancer patients develop resistance to androgen signaling deprivation therapy.

Later-Line Treatments for Metastatic Urothelial Carcinoma of the Bladder

Later-Line Treatments for Metastatic Urothelial Carcinoma of the Bladder

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Researchers propose a treatment algorithm to clarify treatment options beyond the first line for metastatic urothelial carcinoma of the bladder.

Supply Shortages of Bacillus Calmette-Guérin Found to Spur Drug Rationing in Non-Muscle-Invasive Bladder Cancer

Supply Shortages of Bacillus Calmette-Guérin Found to Spur Drug Rationing in Non-Muscle-Invasive Bladder Cancer

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BCG shortages did not appear to influence the incidence of radical cystectomy, but evidence of drug rationing was revealed.

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