In Advanced Hepatocellular Carcinoma, Baseline AFP May Predict Response to Ramucirumab

Share this content:
Baseline α-fetoprotein levels may be a predictive marker for advanced hepatocellular carcinoma receiving ramucirumab.
Baseline α-fetoprotein levels may be a predictive marker for advanced hepatocellular carcinoma receiving ramucirumab.

SAN FRANCISCO—Baseline α-fetoprotein (AFP) levels may be a predictive marker for patients with advanced hepatocellular carcinoma receiving ramucirumab as second-line treatment, a study (Abstract 232) presented this week at the 2015 Gastrointestinal Cancers Symposium has shown.

The REACH study was a phase 3 study that evaluated the safety and efficacy of ramucirumab alone for the treatment of patients with advanced hepatocellular carcinoma who had previously received sorafenib. In this pre-specified subgroup analysis, researchers looked at the effect of baseline AFP levels ≥400ng/mL on ramucirumab efficacy.

Results showed that among the 250 patients with baseline AFP ≥400ng/mL treated with ramucirumab or placebo, the overall survival hazard ratio was 0.67 (95% CI: 0.51 – 0.90; P = 0.0059). The median overall survival was 7.8 and 4.2 months for the ramucirumab and placebo groups, respectively.

RELATED: eNOS Polymorphisms May Influence Prognosis in Hepatocellular Carcinoma Treated with Sorafenib

Among the 417 patients with baselines AFP ≥1.5 x ULN, the median overall survival was 8.6 and 5.7 months for the ramucirumab and placebo groups, respectively (HR = 0.749; 95% CI: 0.603 – 0.930; P = 0.0088).

Analyses of the significance of the interaction between baseline AFP cutoffs, ≥400ng/mL and ≥1.5 x ULN, and ramucirumab treatment effect showed P-values of 0.0272 and 0.0372, respectively.

In regard to safety, patients in these subgroups had a similar safety profile as those in the overall safety population.

Reference

  1. Zhu AX, Ryoo B-Y, Yen C-J, et al.  Ramucirumab (RAM) as second-line treatment in patients (pts) with advanced hepatocellular carcinoma (HCC): Analysis of patients with elevated α-fetoprotein (AFP) from the randomized phase III REACH study. J Clin Oncol. 2015;33:(suppl 3; abstr 232).

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs