Similarities, Differences Between Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas

Share this content:
Comprehensive genomic profiling shows promise in advanced esophageal squamous cell carcinomas and adenocarcinoma.
Comprehensive genomic profiling shows promise in advanced esophageal squamous cell carcinomas and adenocarcinoma.

SAN FRANCISCO—Comprehensive genomic profiling (CGP) shows significant promise in identifying clinically revelant genomic alterations (CRGA) in both advanced esophageal squamous cell carcinomas (ESCC) and esophageal adenocarcinoma (EAC) and has the potential to influence the use of clinical outcome altering targeted therapies in both types of cancer, a study (Abstract 7) presented this week at the 2015 Gastrointestinal Cancers Symposium has shown.

Although EAC is more common than ESCC, both are relatively rare cancers in the United States. Therefore, researchers sought compare the genomic profiles of ESCC and EAC in order to identify potential targets for drug therapy.

For the study, researchers extracted DNA from 54 patients with clinically advanced ESCC and 234 patients with EAC. They then used GCP to identify CRGA.

RELATED: AMG-337 May Be Effective for MET-Amplified Gastrointestinal Tumors

Results showed that CRGA occurred in 93% of cases of ESCC and 92% of EAC, but EAC had more CRGA than ESCC. The CRGA more common in ESCC than EAC were PIK3CA, PTEN, and NOTCH1, and the CRGA more common in EAC than ESCC were KRAS and ERBB2.

In addition, researchers identified other genomic alterations that were significantly different between the two cancer types: SMAD4, RB1, SOX2, and NFE2L2, all of which were common in ESCC. Human papillomavirus (HPV)-16 and HPV-18 were also identified in 4% and 2% of ESCC, respectively.

Reference

  1. Wang K, Chmielecki J, Ali SM, et al. Comprehensive genomic profiling (CGP) of advanced stage esophageal squamous cell carcinomas (ESCC) and esophageal adenocarcinomas (EAC) to reveal similarities and differences. J Clin Oncol. 2015;33:(suppl 3; abstr 7).

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs