Diabetes Raises Risk of Head and Neck Cancer

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Retrospective cohort study in Taiwan shows significantly increased risk of cancer.
Retrospective cohort study in Taiwan shows significantly increased risk of cancer.

Patients newly diagnosed with diabetes have an increased risk of developing head and neck cancer, according to a study published online in JAMA Otolaryngology-Head & Neck Surgery.

Kuo-Shu Tseng, Ph.D., from the Tainan University of Technology in Taiwan, and colleagues used data from Taiwan's Longitudinal Health Insurance Research Database to examine the risk of head and neck cancer among patients with diabetes. A total of 89,089 patients newly diagnosed with diabetes and controls without diabetes and matched for comorbidities, sex, and age were included in the analyses.

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The researchers found that compared with the risk of a first malignant tumor in the control group the incidence of head and neck cancer was found to be higher in patients newly diagnosed as having diabetes (adjusted hazard ratio, 1.48). In patients with diabetes versus controls, the risks of oral cancer, oropharyngeal cancer, and nasopharyngeal carcinoma were significantly increased (adjusted hazard ratios, 1.74, 1.53, and 1.40, respectively).

"Diabetes is associated with an increased risk of developing head and neck cancer," the authors write.

  1. Tseng, Kuo-Shu, et al. "Risk of Head and Neck Cancer in Patients with Diabetes Mellitus." JAMA Otolaryngology-Head & Neck Surgery. doi:10.1001/jamaoto.2014.1258. July 24, 2014.

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