Primary Surgery, Concurrent Chemoradiation in Head & Neck Cancer Provide Similar Outcomes

Share this content:

the Cancer Therapy Advisor take:

Patients with advanced, non-metastatic head and neck squamous cell carcinoma experience similar outcomes when treated with either primary surgery or concurrent chemotherapy and radiotherapy (CRRT), according to a recent study published in Cancer.

However, patients with cancers of the oral cavity or maxillary sinus should consider primary surgery as the main treatment modality.

Narayanan Gopalakrishna Iyer,  PhD, MBBS, and colleagues at the National Cancer Centre in Singapore examined 119 patients with stage ¾ resectable head and neck squamous cell carcinoma, with 60 who had undergone primary surgery and 59 who were adminstered CRRT. Median follow-up for surviving patients was 13 years.

They found no statistically significant difference in overall survival or disease-specific survival in either group when analyzing the entire cohort.

For patients with cancer of the oral cavity or maxillary sinus, however, survival was significantly better in those who had undergone primary surgery.

“These long-term results demonstrate a significant advantage for primary surgery in patients with cancers of the oral cavity or maxillary sinus,” the authors concluded.

Cetuximab Plus PX-866 Not Effective for Recurrent or Metastatic Head and Neck Squamous Cell Cancer
Head and neck squamous cancer patients experience similar outcomes when treated with either primary surgery or CRRT.
The current study was performed to report the long-term results of a trial comparing concurrent chemotherapy and radiotherapy (CCRT) with surgery and adjuvant radiotherapy (RT) in patients with stage III/IV nonmetastatic head and neck squamous cell carcinoma.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs