Head and Neck Cancer

ASCO Critiques Guideline for HPV Testing in Head and Neck Cancer

ASCO Critiques Guideline for HPV Testing in Head and Neck Cancer

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ASCO reviewed and critiqued the College of American Pathologists guideline for human papillomavirus testing in head and neck cancer.

Gender-Based Differences in Chemotherapy: Efficacy and Safety

Gender-Based Differences in Chemotherapy: Efficacy and Safety

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Women and men were found to react differently to treatment with chemotherapy, although gender-based survival differences were not observed.

Immunotherapy Combo in Head and Neck Cancer Shows Activity in Phase 2 Trial

Immunotherapy Combo in Head and Neck Cancer Shows Activity in Phase 2 Trial

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Durvalumab with or without tremelimumab deemed safe and effective in patients with recurrent or metastatic head and neck squamous cell carcinoma.

Moving Targets: Off-Label Prescribing of Targeted Therapies

Moving Targets: Off-Label Prescribing of Targeted Therapies

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By way of the TAPUR study, researchers are attempting to evaluate the activity of targeted therapies when they are used in an off-label setting.

Who Determines What 'Value' Looks Like in Value-Based Cancer Care?

Who Determines What 'Value' Looks Like in Value-Based Cancer Care?

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Evaluation of patient-reported outcomes (PROs) is an important component of measuring quality in cancer care.

Reclassification of Variants of Uncertain Significance: A Q&A With Theodora Ross MD, PhD

Reclassification of Variants of Uncertain Significance: A Q&A With Theodora Ross MD, PhD

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Dr Ross described how genomic reports may need to be updated to account for new insights into a variant's role in cancer.

Pembrolizumab Alone or With Chemotherapy Prolongs OS in Recurrent/Metastatic HNSCC

Pembrolizumab Alone or With Chemotherapy Prolongs OS in Recurrent/Metastatic HNSCC

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Pembrolizumab monotherapy and pembrolizumab plus chemotherapy prolonged OS in recurrent/metastatic HNSCC.

Using ctDNA to Predict Cancer Recurrence and Guide Therapy Selection

Using ctDNA to Predict Cancer Recurrence and Guide Therapy Selection

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A ctDNA testing method has the capability to predict cancer recurrence, which could help guide therapy selections and uncover new drug development opportunities.

Treatment Delays May Mean Worse Survival in Head and Neck Cancer

Treatment Delays May Mean Worse Survival in Head and Neck Cancer

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Prolonged postoperative and radiation intervals were associated with worse survival outcomes in patients with head and neck cancer.

Age-adjusted Comorbidity Predicts Survival in Laryngeal Cancer

Age-adjusted Comorbidity Predicts Survival in Laryngeal Cancer

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Age and pretreatment comorbidities were shown to impact survival outcomes in patients with locally advanced laryngeal cancer.

As HPV-Related Cancer Rates Climb, Experts Scrutinize Barriers to HPV Vaccination

As HPV-Related Cancer Rates Climb, Experts Scrutinize Barriers to HPV Vaccination

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Oropharyngeal cancers have become the most common HPV-associated malignancies in the US, where the rate of vaccination against HPV lags compared with other countries.

Scientists Identify 2 Variables That May Lead to Depression in Head and Neck Cancer

Scientists Identify 2 Variables That May Lead to Depression in Head and Neck Cancer

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These factors influenced the likelihood of depression in patients not given prophylactic antidepressants.

Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?

Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?

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In clinical practice, most physicians and nurse practitioners do not feel comfortable enough with their medical knowledge of cannabis to offer it to patients.

Fall of Star Cancer Researcher Brings Broader Picture Into View

Fall of Star Cancer Researcher Brings Broader Picture Into View

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Dr José Baselga failed to disclose his financial ties to pharmaceutical companies in top-tier journals, causing many to question whether conflicts of interest are being properly reported.

A Simplified Dose Schedule of Cetuximab as a Maintenance Therapy in Head and Neck Cancer May Reduce Drug Toxicities

A Simplified Dose Schedule of Cetuximab as a Maintenance Therapy in Head and Neck Cancer May Reduce Drug Toxicities

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In a small group of head and neck cancer patients, biweekly doses of cetuximab in the maintenance setting appeared to be more tolerable than weekly doses.

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

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More than 90 medical societies have called on the US government to reverse a policy allowing step therapy under Medicare Advantage.

FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

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There is a push to create innovative adaptive trial designs that include more patients and, subsequently, more generalizable data.

Bispecific Antibodies in Cancer

Bispecific Antibodies in Cancer

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Interest in these bioengineered antibodies has been rekindled by the striking success seen in the treatment of some cancers with immunotherapies.

Novel Biomarker COX-2 May Have a Prognostic Role in Nasopharyngeal Carcinoma

Novel Biomarker COX-2 May Have a Prognostic Role in Nasopharyngeal Carcinoma

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The biomarker may be a predictor of response to treatment and cancer progression in nasopharyngeal carcinoma.

Recreational Marijuana May Improve Quality of Life Outcomes in Head and Neck Cancer

Recreational Marijuana May Improve Quality of Life Outcomes in Head and Neck Cancer

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Previous studies have demonstrated that patients with head and neck cancer experience high levels of stress, anxiety, and psychosocial distress throughout the course of the disease.

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

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Approximately half of patients with advanced cancer who are enrolled in phase 1 clinical trials do not know the ultimate goal of the study.

Triclosan and Cancer Risk: Is There a Link?

Triclosan and Cancer Risk: Is There a Link?

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Some studies suggest triclosan could have oncogenic properties, but more research is needed to confirm a causal link.

Pazopanib Plus Cetuximab May Be Effective and Well-Tolerated in Head and Neck Cancer

Pazopanib Plus Cetuximab May Be Effective and Well-Tolerated in Head and Neck Cancer

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Only a few studies have investigated the effectiveness of pazopanib and cetuximab, an angiogenesis inhibitor and EGFR inhibitor, respectively, for head and neck squamous cell carcinoma.

Pembrolizumab May Lead to Favorable Long-Term Outcomes in Head and Neck Cancer

Pembrolizumab May Lead to Favorable Long-Term Outcomes in Head and Neck Cancer

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The anti-programmed death 1 (PD-1) antibody pembrolizumab was determined to be an effective second-line option for patients with head and neck cancers.

Is Genomic Medicine Failing Minority Patients?

Is Genomic Medicine Failing Minority Patients?

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Racial minorities are poorly represented in genomic research databases, raising important questions about whether or not all patients will benefit equally from advances in precision oncology.

Motolimod Combination Therapy Does Not Improve Survival in Squamous Cell Carcinoma of the Head and Neck

Motolimod Combination Therapy Does Not Improve Survival in Squamous Cell Carcinoma of the Head and Neck

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Previous studies have demonstrated that motolimod can induce positive immune responses, but it did not improve outcomes in the first-line setting in squamous cell carcinoma of the head and neck in the featured study.

<i>ARID1A</i> Mutations Might Predict Tumor Response to Immunotherapy

ARID1A Mutations Might Predict Tumor Response to Immunotherapy

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New findings bolster the case for the predictive utility of ARID1A mutations.

Liquid Biopsies and Cancer Detection: New Test Assesses Levels of Circulating Proteins for Early-Stage Diagnosis

Liquid Biopsies and Cancer Detection: New Test Assesses Levels of Circulating Proteins for Early-Stage Diagnosis

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A new test has been shown to be capable of identifying eight different cancers by assessing levels of circulating proteins along with mutations in cell-free DNA.

Understanding Telomerase: Higher Quality Images Give Insight Into Developing New Agents for Inhibition

Understanding Telomerase: Higher Quality Images Give Insight Into Developing New Agents for Inhibition

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Telomerase plays a crucial role in tumor proliferation, and a better understanding of its structure will pave the way for new drug development.

Efficacy and Hyperemesis Syndrome Associated With Cannabinoid Use in Cancers ― In the Clinic

Efficacy and Hyperemesis Syndrome Associated With Cannabinoid Use in Cancers ― In the Clinic

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Many clinical trials and systematic reviews note that the use of cannabinoids also comes with adverse events, including a clinical entity that has been gaining evidence in the literature over the last decade called cannabinoid hyperemesis syndrome.

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