Hematologic Cancers News
No Benefit Seen From HSCT in Hypodiploid B-ALL
Clinical outcomes of patients with hypodiploid B-ALL are poor compared with those with B-ALL not characterized by hypodiploidy, according to researchers.
Ambient Benzene Exposure and Risk of Hematologic Malignancies
Researchers examined low-level estimates of ambient benzene to investigate whether it was associated with increased cancer incidence across a nationwide cohort.
Ibrutinib Plus Nivolumab in 4 Cohorts of Patients With R/R NHL or CLL
According to results of an exploratory study, patients with Richter transformation may benefit from treatment with ibrutinib plus nivolumab.
Assessment of Treatment Intensity as a Predictor of Benefit in DLBCL
Patients with newly-diagnosed DLBCL receiving R-CHOP at or near full-dose intensity have improved overall survival, according to study authors.
A 5-Feature Radiomics Model to Predict Refractory Disease in Early-Stage Hodgkin Lymphoma
A study of the use of precision medicine-based "radiomic" features to evaluate risk of refractory disease in early-stage Hodgkin lymphoma showed promising results.
Low-Dose Lenalidomide Maintenance in Older Patients With PCNSL
Given the high likelihood of comorbidities and poor performance status in older patients with PCNSL, alternative treatment approaches are needed for this population of patients.
FDA Provides Update on Breast Implant-Associated Anaplastic Large Cell Lymphoma
The US FDA provided updated information to women with breast implants and their health care providers on the risk of developing a specific type of lymphoma.
Blinatumomab-Ponatinib Salvage Therapy in B-Cell Acute Lymphoblastic Leukemia: Case Report of Benefit
Patients with B-ALL may benefit from sequential treatment with CD19 CAR-T therapy and anti-CD19 bispecific T-cell engager therapy regardless of sequence, according to a case study report.
NICE Recommends Use of Tisagenlecleucel for Adults With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Adults in the UK with R/R DLBCL and their health care providers now have the option of considering treatment with tisagenlecleucel, a CAR-T cell therapy.
The Incidence of Some Obesity-Related Cancers Is Increasing Among Young Adults
Obesity in childhood and adolescence may be related to the disproportionate rise in certain obesity-related cancers in younger adults, according to authors.
Expression Levels of NOTCH3 Minus Exon 16 as a Potential Prognostic Biomarker in Diffuse Large B-Cell Lymphoma
Spliced events in NOTCH genes may facilitate risk stratification for patients with certain subtypes of DLBCL.
FDA Grants IND Clearance for ALLO-501, an Allogeneic CAR-T Candidate
Initiation of a phase 1 clinical trial of ALLO-501, an allogeneic CAR-T candidate, in patients with NHL is planned for early 2019.
EBV-Positive Lymphomas Associated With Somatic Alterations in Genes Encoding for PD-L1 and PD-L2
Detection of specific mutations in genes encoding for PD-L1 and PD-L2 may help predict which patients with lymphoma will benefit from immune checkpoint inhibitor therapy.
Leading Cause of Death in Follicular Lymphoma Remains Disease Itself
The leading cause of death for patients with follicular lymphoma was the disease itself, despite gains in survival due to rituximab treatment.
Long-Term Outcomes of Axicabtagene Ciloleucel: ZUMA-1
In the ZUMA-1 trial, axicabtagene ciloleucel showed durable responses and no new safety concerns in patients with relapsed or refractory large B-cell lymphoma.
Primary End Point Not Met in Trial Testing Nivolumab Monotherapy for DLBCL
Nivolumab monotherapy for R/R DLBCL failed to confer improved objective response rates, but did produce durable responses in 3 individuals.
Chemoimmunotherapy Regimen Confers Benefit in Double Expressor DLBCL
Patients younger than 65 with double expressor diffuse large B-cell lymphoma had better outcomes with dose-adjusted EPOCH plus rituximab than R-CHOP.
Single-Cell Examination Can Provide Insights into Tumor Microenvironment
Cellular examination of follicular lymphoma reveals malignant B-cell types, coexpression of T-cell immune checkpoints.
Takeda to Collaborate With MSKCC on CAR-T Therapies for Multiple Myeloma
Takeda will work with Memorial Sloan Kettering Cancer Center to develop CAR-T therapies for multiple myeloma.
Depth of Response Translates Into Real-World Benefit in Multiple Myeloma
Depth of response corresponded to overall survival and time to next treatment in real-world patients with relapsed/refractory multiple myeloma.
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