Patterns of Cardiotoxicity Associated with Carfilzomib
the Cancer Therapy Advisor take:
According to a new case series published in the Journal of Cardiac Failure, there was a common clinical syndrome of dyspnea with left ventricular systolic and/or diastolic dysfunction caused by carfilzomib, a proteasome inhibitor used for the treatment of multiple myeloma.
Despite the lack of clinical evidence that proteasome inhibitors result in heart failure in humans, studies with animal models and case reports with bortezomib, an older proteasome inhibitor than carfilzomib, have suggested that proteasome inhibitors do cause cardiotoxicity. In this case series, researchers describe six patients with relapsed or refractory multiple myeloma who experienced significant cardiotoxicity with carfilzomib. All patients experienced shortness of breath associated with left ventricular systolic and/or diastolic dysfunction.
The cardiotoxicity was mostly reversible when carfilzomib was discontinued immediately and medications that treat heart failure were initiated. For some patients, reinitiation of carfilzomib with dose modification was possible.
Carfilzomib (Kyprolis) was approved by the U.S. Food and Drug Administration in 2012 for the treatment of patients with multiple myeloma who have received at least two prior therapies, including bortezomib and an immunomodulatory agent.
Patients receiving carfilzomib should be monitored for cardiac complications and managed promptly. Patients with a history of cardiac abnormalities may be at greater risk for cardiac complications.
Common clinical syndrome of dyspnea with left ventricular systolic and/or diastolic dysfunction caused by carfilzomib.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Metastatic Prostate Cancer Responds to Novel Radiation Therapy
- Clinical Applications of Liquid Biopsies in Cancer
- Two-Drug Combination Superior to Sunitinib in Patients With Untreated Advanced Renal Cell Carcinoma
- Radical Prostatectomy Compared With Watchful Waiting in Localized Prostate Cancer
- Immunotherapy in Glioblastoma: Peaks and Pits
- OS and PFS End Points Not Met in Phase 3 Trial of Pembrolizumab in Advanced HCC
- No Benefit Observed With Osimertinib Plus Durvalumab in EGFR-Mutated NSCLC
- Evidence of the Role of Circulating Insulin in Renal Cell Carcinoma Risk
- Treatment Guidelines in Cancer: Assessing Industry Influence on Recommendations
- American Society of Breast Surgeons Recommends Genetic Testing for All Patients With Breast Cancer