Pacritinib Improves Spleen Volume Recovery in Advanced Myelofibrosis

Share this content:
Pacritinib, an investigational oral multikinase inhibitor, improves spleen volume reduction among high-risk patients with advanced myelofibrosis.
Pacritinib, an investigational oral multikinase inhibitor, improves spleen volume reduction among high-risk patients with advanced myelofibrosis.

Pacritinib, an investigational oral multikinase inhibitor, improves spleen volume reduction among high-risk patients with advanced myelofibrosis, according to preliminary results from the phase 3 PERSIST-2 clinical trial.1

Investigators enrolled 311 patients with myelofibrosis whose platelet counts were less than 100,000/μL. Among the 221 patients who reached week 24, treatment with pacritinib was associated with an improved response rate in spleen volume reduction, in contrast with the best available therapies, including ruxolitinib.

The other co-primary end point of greater than 50% reduction in Total Symptom Score was not met, though preliminary data suggest a trend toward significant results.

RELATED: Imetelstat Active in Myelofibrosis, But May Cause Myelosuppression

The most frequently reported treatment-emergent adverse events among patients treated with pacritinib were diarrhea, nausea, and vomiting, which were generally manageable.

Additional findings will be submitted for presentation at an upcoming scientific meeting.                             

Reference

  1. CTI Biopharma announces top-line results from PERSIST-2 phase 3 trial of pacritinib for high-risk patients with advanced myelofibrosis. CTI BioPharma website. http://investors.ctibiopharma.com/phoenix.zhtml?c=92775&p=RssLanding&cat=news&id=2197807. Updated August 29, 2016. Accessed August 29, 2016.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs