New Gene Therapy May Prove Useful Against Cancer Patients' Fungal Infections
the Cancer Therapy Advisor take:
The Sleeping Beauty gene transfer system “awakens” transposon, which are DNA sequences that researchers find useful for altering DNA inside human cells. Sleeping Beauty exploits the transposon so that it can relocate genetic material with a “cut and paste” approach.
According to a study published in Proceedings of the National Academy of Sciences, researchers fought infections by invasive Aspergillus fungus by modifying T cells with the Sleeping Beauty gene transfer system. Research leader Laurence Cooper, MD, PhD, and researchers at The University of Texas MD Anderson Cancer Center used Sleeping Beauty to make T cells express chimeric antigen receptors (CARs), which caused the T cells to target sugar molecules in Aspergillus cell walls. This approach may prove useful for immunosuppressed patients, such as patients with hematopoietic stem cell transplants, which treat blood or bone marrow cancers.
Dimitrios Kontoyiannis, MD, ScD, said although antifungal therapies are available, the drugs’ effectiveness is compromised due to the patient’s weakened immune system from hematopoietic stem cell transplants as well as emerging resistance to antifungals. Cooper said that his research team studied their new gene therapy against fungus due to CARs’ successful treatment of patients with B-cell malignancies.
Redirecting T-cell specificity opens up the potential for more investigations of its effects on other pathogens and malignancies.
New Gene Therapy May Prove Useful Against Cancer Patients’ Fungal Infections
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Patient-Reported Outcomes in Oncology Expected to Make Regulatory Waves
- Metastatic Prostate Cancer Responds to Novel Radiation Therapy
- FDA Provides Update on Breast Implant-Associated Anaplastic Large Cell Lymphoma
- Q&A With Mark B. Gerstein, PhD, on Diagnostic Genomic vs Exomic Sequencing
- Immune Signature for Renal Cell Papillary Carcinoma Predicts Outcome
- Nivolumab-Ipilimumab Survival Benefit in Advanced RCC Confirmed
- Two-Drug Combination Superior to Sunitinib in Patients With Untreated Advanced Renal Cell Carcinoma
- Adding Chemotherapy to Radiation Post-Radical Cystectomy Improves Survival in Urothelial Carcinoma
- Radiation, Chemotherapy Not Beneficial in Localized Upper Tract Urothelial Carcinoma
- Radical Cystectomy Superior to Trimodal Therapy for Muscle-Invasive Bladder Cancer