Particular Donor Genotype Lowers Leukemia Relapse Rate

Share this content:
Particular Donor Genotype Lowers Leukemia Relapse Rate
Particular Donor Genotype Lowers Leukemia Relapse Rate

(HealthDay News) -- Patients with acute myeloid leukemia who receive a stem cell transplant from a donor with activating killer-cell immunoglobulin-like receptor (KIR) genotype KIR2DS1, which has ligand specificity for human leukocyte antigen (HLA)-C2 antigen, have a lower rate of relapse, according to a study published in the Aug. 30 issue of the New England Journal of Medicine.

Jeffrey M. Venstrom, M.D., from the Memorial Sloan-Kettering Cancer Center in New York City, and colleagues reviewed data from 1,277 patients with acute myeloid leukemia who had received an allogeneic hematopoietic stem-cell transplant from an unrelated donor. They performed genotyping of KIR and assessed the clinical impact of donor KIR genotype.

The researchers found that the relapse rate was significantly lower for patients whose donors were positive for the KIR2DS1 genotype (hazard ratio, 0.76). This effect appeared to be mediated through HLA-C, with significant protection observed from donors homozygous or heterozygous for HLA-C1 antigens (rate of relapse, 24.9) but not those homozygous for HLA-C2 antigens (rate of relapse, 37.3 percent; hazard ratio [HR], 0.46). In those with a mismatch at a single HLA-C locus, the relapse rate was significantly lower if the donor was positive for KIR2DS1 (HR, 0.40). The KIR3DS1 genotype in positive genetic linkage disequilibrium with KIR2DS1 was associated with significantly lower mortality (HR, 0.83).

"Activating KIR genes from donors were associated with distinct outcomes of allogeneic hematopoietic stem-cell transplantation for acute myeloid leukemia," Venstrom and colleagues conclude.

The study was partially funded by the pharmaceutical and biotechnology industries.

Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs