Ruxolitinib Superior to Standard Therapy for Polycythemia Vera
the Cancer Therapy Advisor take:
Ruxolitinib was superior to standard therapy in patients intolerant to or inadequately responded to hydroxyurea for the treatment of polycythemia vera, a study published in the New England Journal of Medicine has shown.
or the phase 3, researchers sought to investigate the safety and efficacy of ruxolitinib, a Janus kinase (JAK) 1 and 2 inhibitor, as second-line treatment for polycythemia vera. Researchers enrolled 222 phlebotomy-dependent patients with splenomegaly and randomly assigned them 1:1 to receive either ruxolitinib or standard therapy.
Results showed that 21% of those in the ruxolitinib group achieved hematocrit control through week 32 and had at least a 35% decrease in spleen volume at week 32 compared with only 1% of patients in the standard therapy group (P < 0.001).
In addition, 60% and 20% of those in the ruxolitinib and standard therapy groups, respectively, achieved hematocrit control, while 38% of the ruxolitinib group versus 1% of the standard therapy group had a 35% decrease in spleen volume.
Furthermore, 24% of ruxolitinib patients achieved a complete hematologic remission versus 9% of standard-therapy patients (P = 0.003). In regard to safety in the ruxolitinib group, 2% of patients experienced grade 3 or 4 anemia, 5% had grade 3 or 4 thrombocytopenia, and 6% developed a herpes zoster infection.
Based on these study results, the U.S. Food and Drug Administration approved ruxolitinib for the treatment of patients with polycythemia vera in Decemeber 2014, making it the first drug approved by the FDA for this condition.
Ruxolitinib was superior in patients intolerant to or inadequately responded to hydroxyurea for the treatment of polycythemia vera.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Plastics and Cancer
- Cabozantinib Shows Promising Activity in Osteosarcoma and Ewing Sarcoma
- Real-World Study Shows High Response Rates to T-VEC in Early Metastatic Melanoma
- Using ctDNA to Predict Cancer Recurrence and Guide Therapy Selection
- Atezolizumab and Nab-Paclitaxel Prolonged PFS in Metastatic Triple-Negative Breast Cancer
- Infections in Primary Immune Thrombocytopenia Associated With Low Platelet Count
- Expert Panel Provides Recommendations for Running Trials on Intratumoral Immunotherapy
- Large Acute Myeloid Leukemia Dataset Could Help Identify Targeted Treatments
- Treatment of H. pylori Increased Platelet Count in ITP
- Reclassification of Variants of Uncertain Significance: A Q&A With Theodora Ross MD, PhD