TP53 Mutations Present in HPV-Negative Vulvar Cancer
In a whole-exome analysis, the most common mutations occurred in TP53, and mutations in other known cancer-associated genes were identified in women with HPV-negative vulvar cancer.
Home
Treating Strategies for Patients With Relapsed/Refractory Acute Myeloid Leukemia
Although numerous clinical studies have aimed to treat AML, most results have been disappointing, according to authors of a publication in Blood.
Keytruda Approved as First-Line Treatment of MSI-H or dMMR Colorectal Cancer
The FDA has approved Keytruda (pembrolizumab; Merck), a programmed death receptor-1 -blocking antibody, as monotherapy for the first-line treatment of patients with unresectable or metastatic microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer.
Phesgo Approval Allows for Faster Administration of Pertuzumab and Trastuzumab
The FDA has approved Phesgo™ (pertuzumab, trastuzumab, hyaluronidase-zzxf; Genentech), in combination with chemotherapy, for the treatment of early and metastatic HER2-positive breast cancer.
Active Anticancer Treatment Associated With Poor COVID-19 Prognosis
Genome-wide association studies have revealed over 180 SNPs associated with increased breast cancer risk.
Polygenic Risk Score Tool Predicts Breast Cancer Risk in Latina Women
Polygenic risk scores incorporating scores of SNPs associated with breast cancer risk have been used as breast cancer risk-stratification tools.
Can Advocacy Groups Provide Useful Patient-Centered Data?
A survey presented during ASCO20 found that patients who considered themselves adequately informed felt “in control” most days.
Study Finds Vancomycin Increased Risk for Cytomegalovirus Reactivation After Hematopoietic Cell Transplant
A retrospective study of CMV-seropositive adults receiving allogeneic HCT and CMV-seronegative HLA-matched sibling donors found that vancomycin exposure before HCT increased the risk for CMV reactivation.
Methotrexate-Induced Acute Kidney Injuries in Patients With Hematologic Malignancies
Upon starting methotrexate treatment, LDH and albumin levels may be signals for AKIs in patients with hematologic malignancies.
Incidence of VTE, Major Bleeding High in Primary CNS Lymphoma
VTE risk up with chemotherapy, radiation therapy; major bleeding risk up with PE, proximal DVT.
Want to read more?
Please login or register first to view this content.
Next post in Lymphoma
