Summary

There is no doubt that patients with diabetes experience certain cancers at higher than expected rates. But why this occurs still remains a question. The findings reviewed here only serve to underscore the difficulty of elucidating specific mechanisms in the complex relationship between diabetes and cancer. The postulated mechanisms include direct action through pathophysiologic changes in T2DM, shared risk factors, and unintended long-term effects of antihyperglycemic therapies.1,39 What drives the association remains unclear, and has attracted increasing interest as rates of T2DM continue to rise in the United States and elsewhere.1,8


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References

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