Frailty Predicts Higher In-Hospital Mortality After Radical Cystectomy
Frail patients are more likely than non-frail patients to experience adverse perioperative outcomes after radical cystectomy, a study found.
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Bladder Cancer News
Poor Diabetes Control Linked to Worse NMIBC Outcomes
Among patients with non-muscle-invasive bladder cancer, those with diabetes and HbA1c levels below 7% have shorter progression-free survival.
Earlier Pembrolizumab Use May Be Beneficial in mUC
In a phase 2 study, patients with metastatic urothelial carcinoma who had stable disease on first-line platinum-based chemotherapy experienced a delay in disease progression when switched to pembolizumab.
Adverse Events Associated With Outcomes in PD-1/PD-L1–Treated Urothelial Carcinoma
An FDA pooled analysis suggests that certain AEs were associated with response and overall survival in PD-1/PD-L1-treated urothelial cancer.
Enfortumab Vedotin Yields High Response Rate in Advanced Urothelial Cancer
The investigators said the data justify and support the submission of enfortumab vedotin for consideration under FDA’s accelerated approval pathway.
Inactivating Mutations in Genes Encoding for Components of the mSWI/SNF Complex May Be Associated With Improved OS in Immunotherapy-Treated Patients
The identification of biomarkers of response and resistance to immune checkpoint inhibitors remains an active area of research.
No Surgery in Nearly 11% of Localized UTUC Cases
In a study, median survival time was significantly shorter among patients managed nonsurgically rather than surgically for localized upper tract urothelial carcinoma.
UTUC Recurrence Risk Lowered With Adjuvant Chemotherapy
Adjuvant chemotherapy given to patients following underwent radical surgery for locally advanced upper tract urothelial carcinoma was associated with a significantly decreased risk of tumor recurrence.
First-in-Class, Targeted Therapy Approved for Metastatic Bladder Cancer
The approval was supported by data from a phase 2 multicenter, open-label, single-arm trial (N=87) of patients with locally advanced or metastatic bladder cancer with FGFR3 or FGFR2 genetic alterations that had progressed following treatment with chemotherapy.
Bladder Cancer Risk Elevated in Statin Users
In a large population-based study in Sweden, statin users had significant 31% increased odds of nonmuscle-invasive bladder cancer compared with nonusers.
The Predictive Ability of a Cancer Subtype Ontology Assignment
The Cancer Subtype Ontology resource includes 840 different cancer subtypes, many of which are novel.
High Monocyte-to-Lymphocyte Ratio Predictive of OS in Advanced Gallbladder Cancer
A high monocyte-to-lymphocyte ratio and a high platelet-to-lymphocyte ratio were predictive of poor OS in patients with advanced gallbladder cancer treated with chemotherapy.
Adding Chemotherapy to Radiation Post-Radical Cystectomy Improves Survival in Urothelial Carcinoma
Postoperative radiation therapy with adjuvant chemotherapy prolonged disease-free survival and overall survival in patients with locally advanced urothelial carcinoma.
Radiation, Chemotherapy Not Beneficial in Localized Upper Tract Urothelial Carcinoma
In a study of patients receiving non-surgical treatment for localized upper tract urothelial carcinoma, radiation or chemotherapy provided no overall survival benefit.
Radical Cystectomy Superior to Trimodal Therapy for Muscle-Invasive Bladder Cancer
Trimodal therapy for patients with muscle-invasive bladder cancer is associated with worse cancer-specific and overall survival and higher costs compared with radical cystectomy.
Pembrolizumab Shows Promise for BCG-Unresponsive Bladder Cancer
Pembrolizumab, a PD-1 inhibitor, demonstrated antitumor activity in patients with high-risk BCG-unresponsive carcinoma in situ.
Bladder Cancer Response to Bacillus Calmette-Guérin May Be Linked to Urine Microbiome
New evidence suggests variation in the bacterial composition of urine is associated with response BCG among patients with non-muscle-invasive bladder cancer.
Post-Cystectomy Short-Term Complications Not Hiked by NAC
Researchers found no significant difference in 30-day postoperative complications between patients who received neoadjuvant chemotherapy and those who did not.
FCT Compared With GD for Muscle-Invasive Bladder Cancer
An established chemoradiation regimen is compared with gemcitabine and once-daily radiation in the selective bladder-sparing treatment of muscle-invasive bladder cancer.
Frailty Assessment May Benefit Patients Undergoing Radical Cystectomy
Older patients should be routinely assessed prior to radical cystectomy to guide both
preoperative and postoperative care.
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