Sterile Pyuria in UTUC Cases Possibly Predicts Intravesical Recurrence
Sterile pyuria may be a marker of inflammation, which is known to influence carcinogenesis.
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Bladder Cancer News
Variant Histology Predicts Aggressive UTUC
In a study of patients with upper tract urothelial carcinoma, variant vs conventional histology predicted worse survival.
Distal Ureteral Management Methods Compared in UTUC
Intravesical incision of the bladder cuff may be superior to other distal ureteral management techniques, according to investigators.
MMR Deficiency Rare in Urothelial Cancers, but Linked to Immune Response
More studies needed to understand role of MMR deficiency as biomarker of immune response.
OS Benefit Seen for Disease Downstaging With Neoadjuvant Chemotherapy vs Transurethral Resection in Muscle-Invasive Bladder Cancer
Two approaches to downstaging muscle-invasive bladder cancer prior to radical cystectomy include neoadjuvant chemotherapy and transurethral resection.
IMRT a Possible Option for Upper Tract Urothelial Carcinoma
In a small pilot study, all 16 UTUC patients experienced a complete or partial response to IMRT.
Neoadjuvant Chemotherapy Appears Effective for High-Risk UTUC
Some patients with high-risk upper tract urothelial carcinoma experience pathologic downstaging following preoperative chemotherapy.
PTRF Biomarker May Predict UTUC Progression, Survival
In a study, high PTRF expression indicated clinically aggressive UTUC in both Taiwanese and Caucasian patients.
Lymph Node Dissection Ups Survival in Higher-Stage UTUC
A study found that patients with more advanced-stage upper tract urothelial carcinoma had a higher prevalence of lymph node metastasis.
Survey Reveals Perspective on Use of Support Garments Varies Among Patients With a Urostomy
Patients’ survey responses ranged from the garments cause discomfort to they alleviate discomfort. Some responses indicated patients face a possible trade-off between comfort and protection in finding the optimal support garment.
Bladder Cancer Surgery Safe Following Neoadjuvant Immunotherapy
Toxicity profile and readmission rates among patients who underwent radical cystectomy and pelvic lymph node dissection following neoadjuvant pembrolizumab are in line with previously published series reporting 90-day outcomes after RC with or without neoadjuvant chemotherapy.
Keytruda Approved for BCG-Unresponsive, High-Risk Non-Muscle Invasive Bladder Cancer
The Food and Drug Administration (FDA) has approved Keytruda (pembrolizumab; Merck) for the treatment of patients with Bacillus Calmette-Guerin (BCG)-unresponsive, high-risk, non-muscle invasive bladder cancer with carcinoma in situ (CIS) with or without papillary tumors who are ineligible for or have elected not to undergo cystectomy.
FDA Approves Therapy for Advanced Urothelial Cancer
Padcev is the first antibody-drug conjugate approved for advanced urothelial cancer patients.
Upper Tract Urothelial Cancer Treatment Granted Priority Review
In a phase 3 trial, mitomycin gel for instillation showed a complete response rate of 59% of patients with low-grade upper tract urothelial cancer.
Long-Term Cancer Survivors Identify Ongoing Challenges Related to Ostomy Self-Management
In this study, researchers identified 8 common themes related to challenges patients experience with ostomy self-management.
Preoperative Pyuria Predicts Bladder Recurrence After UTUC Surgery
In a small study of patients without a history of bladder cancer who undergo radical nephroureterectomy for upper tract urothelial carcinoma, preoperative pyuria was associated with a 1.7-fold increased risk of intravesical recurrence, a study found.
NAC Increases Pathologic Complete Response Rate in High-Risk MIBC
In a study of patients with high-risk muscle-invasive bladder cancer, patients who received cisplatin-based neoadjuvant chemotherapy had a 3.6 times higher rate of pathologic complete response compared with those who had upfront radical cystectomy.
Immunotherapy + Chemo May Improve Outcomes in Metastatic Urothelial Cancer
First-line treatment with both atezolizumab and platinum-based chemotherapy (PBC) is associated with prolonged progression-free survival vs PBC alone in patients with metastatic urothelial cancer, a study found.
Women Have Lower Relative Survival After Bladder Cancer Diagnosis
In a study, women with bladder cancer had approximately 1.5-fold higher mortality than men — but only in the short term.
Robotic Partial Cystectomy Does Not Hike Positive Surgical Margin Risk
Investigators report finding no significant difference in positive surgical margin rates among open, laparoscopic, and robotic-assisted approaches to partial cystectomy.
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