As glioblastoma progresses, patients experience a decline in health-related quality of life (HRQoL). Delaying this decline is an important treatment goal.
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Adding Bevacizumab Has No Impact on Quality of Life in Glioblastoma
the Cancer Therapy Advisor take:
Adding bevacizumab to standard-of-care treatment of newly diagnosed glioblastoma during a progression-free period may have no impact on health-related quality of life, according to a recent study published online ahead of print in the Journal of Clinical Oncology.
Researchers led by Martin Taphoorn, MD, PhD, of the Medical Center Haaglanden in the Netherlands examined patients who completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaires C30 and BN20 upon each tumor assessment. They converted raw scores to a 100-point scale and evaluated mean changes from baseline scores.
The researchers found that mean changes from baseline did not reach clinically relevant differences in observed patients compared to placebo. Adding bevacizumab to radiotherapy with temozolomide (RT/TMZ) resulted in statistically longer deterioration-free survival across all health-related quality of life items.
Time to deterioration was also found to not be statistically longer in the placebo plus RT/TMZ group.
“The addition of bevacizumab to standard-of-care treatment for newly diagnosed glioblastoma had no impact on health-related quality of life during the progression-free period,” the authors concluded.
