Treatment Reduction in Intermediate-Risk Neuroblastoma Deemed Successful
For specific subsets of patients with intermediate-risk neuroblastoma, an algorithm successfully reduced treatment while maintaining survival outcomes.
Brain Cancer News
BRAIN CANCER ADVISOR
Brain Cancer News
Outcomes Poor Years After Radiation for Pediatric Glioma Survivors
Survivors of childhood low-grade gliomas treated with radiotherapy have poorer neuropsychological and socioeconomic-status (SES) outcomes.
LIBRETTO-121: A Phase 1/2 Trial Investigating LOXO-292 in Pediatric Patients With Advanced Solid or Primary CNS Tumors
A primary outcome measure for phase 1 of the trial is determining the safety of oral LOXO-292.
Computer-Assisted Diagnosis Aids Detection of Glioma Growth
Computer-assisted diagnosis (CAD) can help physicians detect growth of low-grade gliomas.
Entrectinib Shows Activity in Pediatric Brain Tumors and Other Solid Tumors
Entrectinib showed activity and appeared to be safe in pediatric patients with recurrent or refractory solid tumors harboring NTRK1/2/3, ROS1, or ALK aberrations.
Phase 3 Study of Investigative Glioblastoma Tx Halted
AbbVie has halted enrollment in all ongoing studies of depatuxizumab mafodotin, after an Independent Data Monitoring Committee (IDMC) recommended a phase 3 study of the treatment be stopped due to a lack of survival benefit.
Combining CAR-T and BiTE in Models of Glioblastoma Multiforme
This study involved the engineering of CAR-T cells specific for the EGFRvIII antigen to also secrete bispecific T cell engagers (BiTEs) against wild-type EGFR.
Delivery of Alternating Electrical Fields Increases Cell Membrane Permeability in Glioblastoma Multiforme
The researchers speculated that the delivery of alternating electric fields to GBM cells may facilitate the delivery of chemotherapy.
In Mice, Lithium Shown to Reverse Dysfunction Related to Brain Tumor Compression
The neuronal loss and neurological dysfunction caused by solid stress from brain tumors was reversed by lithium in mice models.
Liquid Biopsy of Cerebrospinal Fluid Provides Genomic Info on Brain Tumors
Clinical application of cerebrospinal fluid ctDNA analysis remains unclear.
Where Have All the T Cells Gone?
New research proposes a novel mechanism for how tumors sidestep the immune system in patients with intracranial tumors.
Iobenguane I 131 First FDA-Approved Drug For Pheochromocytoma or Paraganglioma
The FDA based its approval on findings from a single-arm phase 2 study, in which researchers treated 68 patients with iobenguane I 131 intravenous injection.
Risk of Brain Metastasis in Colorectal Cancer Dependent on Tumor Location and Other Metastatic Sites
In patients with colorectal cancer, rectal tumors and lung metastasis appeared to be linked to an elevated risk for brain cancer.
Carboxyamidotriazole Orotate With Temozolomide May Be Active Against Glioblastoma
EGFR-amplified tumors had a high rate of response.
Glioblastoma: Temozolomide, Bevacizumab May Improve Outcomes Among Elderly Patients
Researchers enrolled 66 patients with glioblastoma to evaluate the safety and efficacy of upfront temozolomide with bevacizumab.
Tumor-treating Fields Do Not Negatively Affect Health-related QoL
A previous study demonstrated that tumor-treating field therapy improves progression-free survival and overall survival among patients with glioblastoma.
Pediatric Patients Hospitalized for Pneumonia May Have Elevated Cancer Risk
Short-term incidence of leukemia, lymphoma, and brain cancer may be higher in children who were hospitalized with pneumonia.
Sorafenib Plus Temsirolimus Demonstrates Limited Benefit in Glioblastoma
Over 75% and 73.9% of VEGFi-naive and patients previously treated with a VEGFi, respectively, had at least 1 grade 3 or worse adverse event.
Tumor-treating Fields Improve Glioblastoma Outcomes
Adverse event rates were similar in both trial groups, though patients treated with TTFields were much more likely to have mild to moderate skin toxicity.
Tumor Treating Fields May Improve Glioblastoma Outcomes
TTFs can be self-administered at home by patients; this novel radiation treatment is non-ionizing and delivers electrical fields directly to the brain.
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