|The following article features coverage from the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, Illinois. Click here to read more of Cancer Therapy Advisor‘s conference coverage.|
A study presented at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago reported that patients with early stage, HER2-negative breast cancer may be sufficiently well-treated with docetaxel and cyclophosphamide instead of anthracycline-based chemotherapy.1
The West German Study Group (WSG) phase 3 PlanB trial (ClinicalTrials.gov Identifier: NCT01049425) was designed to test whether 6 cycles of anthracycline-free docetaxel plus cyclophosphamide (arm A) was non-inferior to standard anthracycline-taxane chemotherapy (arm B).
The study was amended to include Oncotype DX for all HR-positive tumors.
Of 3198 enrolled women, 2449 women were randomly assigned — 1222 to arm A and 1227 to arm B. Eighteen percent of these participants had HER2-negative tumors according to central review.
After a median follow up of 61 months, 5-year disease-free survival (DFS) was similar across both groups (89.9% for arm A vs 90.2% for arm B) as was 5-year overall survival (OS; 94.7% for arm A vs 94.6% for arm B).
Recurrence score did not emerge as a predictive factor for anthracycline efficacy. Efficacy differences were not observed in subgroup analyses, which included triple-negative breast cancer and patients with more than 4 lymph nodes’ involvement.
The authors concluded that “patients with early HER2-negative [breast cancer] seem to be sufficiently treated by 6 cycles of docetaxel/cyclophosphamide compared to 4 cycles of [anthracycline-based chemotherapy] followed by 4 cycles of docetaxel — no efficacy differences are evident in high-risk subgroups defined by triple-negative status, nodal status, or high Recurrence Score.”
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Read more of Cancer Therapy Advisor‘s coverage of the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting by visiting the conference page.
- Harbeck N, Gluz O, Clemens MR, et al. Prospective WSG phase III PlanB trial: final analysis of adjuvant 4xEC→4x doc vs. 6x docetaxel/cyclophosphamide in patients with high clinical risk and intermediate-to-high genomic risk HER2-negative, early breast cancer. J Clin Oncol. 2017;35(suppl; abstr 504).