(HealthDay News) — High intake of saturated fats is associated with increased risk of certain subtypes of breast cancer, according to research published online April 9 in the Journal of the National Cancer Institute.
Sabina Sieri, PhD, of the Fondazione IRCCS Istituto Nazionale dei Tumori in Milan, and colleagues analyzed data from a prospective cohort of 337,327 women to assess the association between fat intake and development of breast cancer subtypes.
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The researchers found that high intake of fat was associated with increased risk of estrogen receptor (ER)-positive, progesterone receptor (PR)-positive disease, but not ER-negative or PR-negative disease, for the highest versus lowest quintiles of total fat (hazard ratio [HR], 1.20; 95% confidence interval [CI], 1.00 to 1.45) and saturated fat (HR, 1.28; 95% CI, 1.09 to 1.52).
High intake of saturated fat was associated with significantly greater risk of human epidermal growth factor 2 receptor (HER2)-negative disease.
“High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this breast cancer subtype,” the researchers wrote.
