Olaparib significantly prolonged progression-free survival compared with chemotherapy among patients with HER2-negative, BRCA1/2 mutated metastatic breast cancer, according to a press release from AstraZeneca.1

The ongoing international, open-label, phase 3 OLYMPIAD trial (ClinicalTrials.gov Identifier: NCT02000622) randomly assigned 302 patients with metastatic breast cancer who harbored deleterious or suspected deleterious germline BRCA1/2 mutations to receive olaparib orally twice daily or physician’s choice of capecitabine, vinorelbine, or eribulin.

Patients treated with olaparib demonstrated a significant and clinically meaningful improvement in progression-free survival vs those who received standard of care chemotherapy. Initial findings indicate that the safety of olaparib was consistent with previous studies.

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This study is the first randomized trial evaluating the efficacy and safety of a PARP inhibitor to show positive results beyond ovarian cancer.

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Olaparib is approved by the U.S. Food and Drug Administration as monotherapy for patients with deleterious or suspected deleterious germline BRCA-mutated advanced ovarian cancer who have received at least 3 prior lines of chemotherapy.


  1. Lynparza meets primary endpoint in phase III trial in BRCA-mutated metastatic breast cancer [news release]. Wilmington, DE: AstraZeneca; February 17, 2017. https://www.astrazeneca.com/content/astraz/media-centre/press-releases/2017/lynparza-meets-primary-endpoint-in-phase-iii-trial-in-brca-mutated-metastatic-breast-cancer-17022017.html. Accessed February 21, 2017.