Predictors for discontinuing adjuvant hormone therapy in patients with breast cancer have been identified, according to a study published online ahead of print this week in the Journal of Clinical Oncology.
This study was a follow-up of a record-linkage study over a 5-year period in patients with breast cancer who received their first prescription of tamoxifen or aromatase inhibitors. The data were from Stockholm-Gotland Breast Cancer Register, Swedish Prescribed Drug Register, and self-reported questionnaire.
The baseline predictors to discontinue adjuvant hormone therapy were family history of ovarian cancer (HR=1.55; 95% CI: 1.19, 2.02), less than 40 years of age (HR=1.39; 95% CI: 1.08, 1.78), 65 years of age and older (HR=1.15; 95% CI: 1.03, 1.28), Charlson comorbidity index of 2 or greater (HR=1.35; 95% CI: 1.03, 1.76), use of analgesics (HR=1.33; 95% CI: 1.16, 1.52), hypnotics/sedatives (HR=1.24; 95% CI: 1.07, 1.43), gastrointestinal drugs (HR=1.25; 95% CI: 1.08, 1.43), and hormone replacement therapy (HR=1.27; 95% CI: 1.08, 1.49).
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The predictors associated with increased risk of discontinuation during the next four years were use of analgesics (HR=1.22; 95% CI: 1.08, 1.37), hypnotics/sedatives (HR=1.21; 95% CI: 1.07, 1.37), antidepressants (HR=1.22; 95% CI: 1.06, 1.40), gastrointestinal drugs (HR=1.27; 95% CI: 1.13, 1.43), and switching therapy between tamoxifen and aromatase inhibitors (HR=1.50; 95% CI: 1.23,1.83) during the first year of hormonal treatment.