The objective of this study was to explore treatment patterns of TKI therapy (adherence, duration, and switching) among patients with CML in the United States, following the availability of second–generation TKIs. For the US patients studied, the authors found that imatinib was used more frequently than other TKIs in the first–line setting, but there was an increased use of second–generation TKIs in the first–line setting over time (9% in 2008 vs 43% in 2011 were nilotinib or dasatinib users). Only about one fifth of patients switched to a second–line TKI during the period of data collection.

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