A new analysis from the Phase III SELECT (Study of (E7080) LEnvatinib in Differentiated Cancer of the Thyroid) trial of lenvatinib (E7080) in the treatment of radioiodine-refractory differentiated thyroid cancer shows that the level of baseline angiopoietin-2 may be a predictive factor for lenvatinib response and therefore tumour shrinkage and prolonged progression free survival (PFS). Angiopoietin-2 is a protein which regulates the formation of new blood vessels in tumours.
A second analysis from SELECT shows a statistically significant correlation between hypertension and PFS in people with radioiodine-refractory differentiated thyroid cancer. Hypertension is a known adverse event of vascular endothelial growth factor receptor (VEGFR) inhibition and a biomarker for tyrosine kinase inhibitor efficacy in renal cell carcinoma treatment. In the SELECT study, 73% of lenvatinib treated patients experienced hypertension.
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