(HealthDay News) — Coffee consumption is associated with a 40% reduction in the risk of liver cancer, according to a meta-analysis published in the November issue of Clinical Gastroenterology and Hepatology.

Francesca Bravi, Ph.D., from Istituto di Ricerche Farmacologiche “Mario Negri” in Milan, and colleagues identified and performed a meta-analysis of 16 published case-control or cohort studies that examined the association between coffee consumption and liver cancer or hepatocellular carcinoma (HCC), comprising 3,153 cases of HCC.

The researchers found that coffee consumption was associated with a significantly lower risk of HCC (summary relative risk [RR], 0.60 compared with no coffee consumption). Compared with no coffee consumption, the risk was lower for both low consumption (summary RR, 0.72) and high consumption (summary RR, 0.44), with a cut-off between low and high consumption of one or three cups per day depending on study. One additional cup of coffee per day reduced risk (summary RR, 0.80). The association between coffee consumption and HCC risk was not associated with gender, alcohol consumption, or a history of hepatitis or liver disease.

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“From this meta-analysis, the risk of HCC is reduced by 40% for any coffee consumption versus no consumption,” Bravi and colleagues conclude.