Data from U.S. population-based cancer registries show that gallbladder cancer incidence and death rates are highest among female American Indian and Alaska Native persons and differ by region, according to a study published online ahead of print in the journal Cancer Epidemiology, Biomarkers & Prevention.

For the study, researchers from the Centers for Disease Control and Prevention (CDC) examined U.S. gallbladder cancer incidence and death rates for 2007 to 2011 and trends for 1999 to 2011.

Results showed that between 2007 and 2011, two-thirds of gallbladder cancer cases occurred in women, and gallbladder cancer incidence and death rates were three times higher among Alaska Native and American Indian persons compared with non-Hispanic white persons.

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Researchers found that gallbladder cancer incidence rates declined among women but remained constant among men between 1999 and 2011. Death rates also declined among women but leveled off among men after decreasing from 1999 to 2006.

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The study also demonstrated that gallbladder cancer incidence rates increased among black persons, persons less than 45 years of age, and for endocrine tumors.

The authors note that these findings may help to better understand the etiology of gallbladder cancer.


  1. Henley SJ, Weir HK, Jim MA, et al. Gallbladder cancer incidence and mortality, United States 1999-2011. Cancer Epidemiol Biomarkers Prev. 2015. [Epub ahead of print]. doi: 10.1158/1055-9965.EPI-15-0199.