Reductions in the risk of cancer were more pronounced in men and younger patients with vitiligo.
Higher circulating levels of 25(OH)D were also inversely associated with BRAF V600E-mutant colorectal cancer.
Some patients with colorectal cancer are more likely to have disease characterized by a high frequency of mutations, microsatellite instability, and strong immune activation.
A retrospective study of patients with gastric cancer in the United States showed differences in patient- and disease-related characteristics, as well as different frequencies of staging laparoscopy, treatment/surgical approaches, and specific clinical outcomes, for those of Hispanic compared with non-Hispanic ethnicity. This study was published in the Journal of Surgical Oncology. In the US, the incidence of gastric…
The Food and Drug Administration has approved Lonsurf (trifluridine and tipiracil; Taiho Oncology) for the treatment of adult patients with metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma previously treated with at least 2 prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu-targeted therapy. The approval was based…
This study was presented at the 2019 International Congress on Targeted Anticancer Therapies (TAT) in Paris, France, from February 25-27, 2019. Dr Jun Sato of the National Cancer Center Hospital, Japan is the lead author of this study.1 Results from a retrospective study evaluating the focus of early-phase clinical trials of investigational drug candidates in…
High tumor expression of IDO1 may identify whether a patient is likely to respond to immunotherapy, according to study authors.
The impact of direct-acting antiviral therapy was investigated in a large cohort of patients in complete remission following treatment of hepatitis C-related HCC.
Obesity in childhood and adolescence may be related to the disproportionate rise in certain obesity-related cancers in younger adults, according to authors.
This study provides evidence that birinapant could enhance sensitivity to TNF, effectively boosting the activity of CAR-T therapy in solid tumors.
Patients who had hybrid minimally invasive esophagectomy had a lower rate of surgery-related complications than those who had transthoracic open esophagectomy.
Smoking and drinking were related to changes in the esophageal epithelium.
Overall, patient survival was not associated with surgical technique.
Some patients may not be comfortable discontinuing colorectal cancer screening despite minimal benefit associated with the testing.
Researchers are seeking to assess a physical activity program program in patients with gastrointestinal cancer.
Researchers are seeking to determine the feasibility of receiving either postoperative chemoradiation or chemotherapy, based on nodal status at surgery.
Researchers are seeking to assess the initial safety and efficacy of LUM015 imaging of colorectal, pancreatic, and esophageal cancers using the LUM 2.6 imaging device.
A clinical trial found a potential marker to identify the patients with advanced esophageal squamous cell carcinoma who were most likely to respond to nivolumab.
Brain metastases were HER2-positive in nearly one-third of patients with gastrointestinal primary malignancies, suggesting molecular testing may be prudent.
Participant characteristics were similar between surgical treatment groups.