(HealthDay News) — Birth by cesarean delivery is associated with early-onset colorectal cancer (CRC) only in female offspring, according to a study published in JAMA Network Open.

Researchers prospectively examined the association between birth by cesarean delivery and early-onset CRC among offspring. The analysis included 564 adults diagnosed with early-onset CRC from 1991 to 2017 and 2180 matched control individuals.

Individuals born through cesarean delivery did not have significantly higher odds of early-onset CRC than those born via vaginal delivery (adjusted odds ratio [aOR], 1.28; 95%CI, 0.91-1.79) in an analysis adjusted for maternal and pregnancy factors.

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The odds of early-onset CRC were not significantly higher among men born via cesarean delivery (aOR, 1.05; 95%CI, 0.64-1.72), but they were significantly higher among women born by cesarean delivery (aOR, 1.62; 95%CI, 1.01-2.60).

Among women, the odds of colon cancer (aOR, 1.77; 95% CI, 1.05-3.01) were higher than the odds of rectal cancer (aOR, 1.29; 95% CI, 0.42-4.02).

“In this study, females born by cesarean delivery had greater odds of early-onset CRC, suggesting that early-life gut dysbiosis may contribute to early-onset CRC in females,” the researchers wrote.

Two researchers disclosed financial ties to the pharmaceutical industry.

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