(HealthDay News) — The risk of advanced colorectal neoplasms 10 or more years after a negative screening colonoscopy is low, according to a study published in JAMA Internal Medicine.

Researchers assessed the prevalence of advanced colorectal neoplasms at least 10 years after a negative screening colonoscopy among patients in Germany.

There were 120 ,298 patients aged 65 years or older who had a previous negative screening colonoscopy at least 10 years prior. The researchers compared findings in this group with findings in all screening colonoscopies conducted at 65 years or older during the same time period (1.25 million).


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Overall, the prevalence of advanced colorectal neoplasms was 40% to 50% lower in the group of patients who underwent repeated screening colonoscopy 10 or more years after a negative colonoscopy.

At 10 years after a negative screening colonoscopy, the prevalence of advanced colorectal neoplasms was 3.6% among women and 5.2% among men. At 14 or more years after a negative colonoscopy, the prevalence of advanced colorectal neoplasms was 4.9% among women and 6.6% among men.

In the group comprising all screening colonoscopies among patients aged 65 years or older, the prevalence of advanced colorectal neoplasms was 7.1% among women and 11.6% among men.

For repeated colonoscopies at least 10 years after a negative colonoscopy, sex-specific and age-specific prevalence rates of advanced colorectal neoplasms were consistently at least 40% lower among women than men, lower at younger vs older ages, and much lower than for all screening colonoscopies.

“Extension of the currently recommended 10-year screening intervals may be warranted, especially for female and younger participants without gastrointestinal symptoms,” the study authors wrote.

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