Health experts from around the world gathered in Kuala Lumpur, Malaysia, October 1-4 for the 2018 World Cancer Congress. Over the course of 4 days, participants were presented with a wide range of perspectives from a diverse set of speakers from academia, the private sector, and governments. Here are 5 key findings presented at the event:
1. CKS1B could be a target for therapeutic intervention in patients with endometrial cancers. Researchers found evidence that CKS1B might regulate the survival of type 1 and type 2 endometrial cancer cells. Restriction of CKS1B resulted in significant tumor-specific cell death in endometrial cancer cells.
Study: Identification of new molecular targets for treatment of endometrial cancers
2. Combined intravenous and intraperitoneal perfusion therapy extends survival and improves quality of life in patients with gastric cancer. Investigators performed a retrospective analysis on 49 patients with abdominal peritoneal carcinomatosis from gastric cancer. Patients were divided into 2 groups: intravenous chemotherapy and combined intravenous and intraperitoneal chemotherapy. The latter group experienced more favorable results, and treatment produced only mild adverse effects.
Study: Clinical efficacy of combination intravenous and intraperitoneal chemotherapy in the treatment of gastric cancer with peritoneal carcinomatosis
3. A new blood biomarker exhibits high diagnostic accuracy for multiple gastrointestinal, gynecologic, and skin cancers. Progastrin, an inexpensive and diagnostically accurate blood test, may be used for cancer screening prior to tumor localization.
Study: Progastrin, a new blood biomarker for multiple cancers allowing a new strategy for screening, early detection and monitoring
4. Fecal immunochemical testing (FIT) reduces the risk for advanced-stage colorectal cancer (CRC). Over a 10-year period, FIT-positive subjects underwent colonoscopy as a confirmatory exam. FIT screening was especially effective in reducing risk for distal CRC.
Study: Reduction of colorectal cancer mortality and advanced stage incidence after 10 years of fecal immunochemical test screening
5. Cannabis use significantly increases the risk for lung cancer. In a meta-analysis, investigators evaluated 18 observational, 2 cohort, and 16 case-control studies. In addition to increased risk for lung cancer, the researchers found an increased risk for testicular cancer in individuals who had smoked cannabis for 10 years or more.
Study: Cannabis smoking and risk of cancer: a meta-analysis of observational studies
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2018 world cancer congress abstracts. J Global Oncol. 2018;4(suppl 2).