This study suggest that breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death in American women. Postsurgery adjuvant radiotherapy (RT) significantly reduced the local recurrence rate.

However, many patients develop early adverse skin reactions (EASR) that impact quality of life and treatment outcomes. This is the first study to demonstrate that an inflammatory biomarker CRP is associated with RT–induced EASRs, particularly combined with obesity.

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