Cancer deaths increased during the first 2 years of the COVID-19 pandemic in the United States, according to research published in the Journal of the National Cancer Institute.

This increase reversed a previous long-term trend of declining deaths among cancer patients, researchers noted.

For this study, researchers used the US Centers for Disease Control and Prevention’s WONDER database to analyze age-standardized cancer-related deaths between 1999 and 2021.

In the 2 years before the pandemic began (2018-2019), the total number of registered cancer-related deaths was 1,327,399. For 90% of these deaths, cancer was listed as the underlying cause of death.


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In the first 2 years of the pandemic (2020-2021), the number of registered cancer-related deaths increased to 1,379,643, and 88% of these deaths had cancer listed as the underlying cause of death. Cancer was a contributing cause in 29,920 deaths from COVID-19 and in 142,160 non-COVID-19 deaths, the researchers noted.

During 2019-2021, the rate of deaths with multiple causes significantly increased for all cancers (annual percent change [APC], 1.6%). This reversed the decreasing trend from 1999 to 2019 (ACP, -1.6%). Results were similar across cancer types, as seen in the table below.

Changes in Mortality by Cancer Type (Multiple Causes of Death)  

Cancer type

Time period

APC

Respiratory and intrathoracic cancers

1999-2002

-0.5%

2002-2010

-1.9%

2010-2014

-2.9%

2014-2019

-4.2%

2019-2021

-1.1%

 

 

 

Prostate cancer

1999-2014

-3.5%

2014-2019

-.05%

2019-2021

5.1%

 

 

 

Hematologic cancers

1999-2008

-2.0%

2008-2011

-0.9%

2011-2019

-1.7%

2019-2021

4.8%

 

 

 

Digestive cancers

1999-2008

-1.5%

2008-2019

-0.8%

2019-2021

1.5%

 

 

 

Female breast cancer

1999-2001

-1.0%

2001-2007

-2.2%

2007-2015

-1.7%

2015-2019

-0.7%

2019-2021

2.5%

 

 

 

Female genital cancers

1999-2009

-1.1%

2009-2019

-0.5%

2019-2021

2.4%

 

 

 

Urinary tract cancer

1999-2002

0.3%

2002-2015

-0.5%

2015-2019

-1.4%

2019-2021

3.1%

Reference

Fedeli U, Barbiellini C, Han X, Jemal A. Changes in cancer-related mortality during the COVID-19 pandemic in the United States. J Natl Cancer Inst. Published online September 9, 2023. doi:10.1093/jnci/djad191