Fracture incidence is high among patients who have undergone hematopoietic stem-cell transplantation (HSCT), according to a study published online ahead of print in the Journal of Clinical Oncology.

In a retrospective analysis, Xerxes Pundole, MD, MPH, PhD, and fellow researchers at The University of Texas MD Anderson Cancer Center looked at 7,620 patients who had undergone HSCT from 1997 to 2011.

They looked at cumulative incidence rates for fractures with death as a competing risk, and measured for age- and sex-specific incidence rates per person-year against the 1994 National Health Interview Survey and the 2004 National Hospital Discharge Survey.

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The researchers found that 602 patients (8 percent) had developed a fracture, with age, underlying disease, and HSCT type significantly associated with fracture.

Incidence rates for fractures after HSCT were significantly greater compared to the general population , particularly in women who saw an eight-fold greater risk and men aged 45 to 64 who saw a seven- to nine-fold greater risk when matched with survey data.

“The incidence of fractures is compellingly higher after HSCT,” the authors concluded.


  1. Pundole, Xerxes, N., et al. “Increased Incidence of Fractures in Recipients of Hematopoietic Stem-Cell Transplantation.” Journal of Clinical Oncology. doi: 10.1200/JCO.2014.57.8195. [epub ahead of print]. March 16, 2015.