Investigators found an association between miR-146a rs291064 and risk of gastric cancer (GC) development, according to an article published online in the journal European Journal of Cancer Care.
The authors performed a meta-analysis using PubMed and China National Knowledge Infrastructure searches in order to find relevant studies published before July 2014.
In total, seven case-control studies were chosen for the data analysis, including 3,283 cases and 4,535 controls.
Results showed a significant correlation between the genetic polymorphism miR-146a rs291064 and risk of GC under all genetic models (CC vs. GG, OR=0.76, 95% CI: 0.66, 0.87; CC vs. GC+GG, OR=0.84, 95% CI: 0.71, 0.99; CC+GC vs. GG, OR=0.82, 95% CI: 0.73, 0.91).
Furthermore, the authors conducted subgroup analysis by ethnicity and identified an association in Asian that was determined to be statistically significant.
Several studies have investigated the associations between miR-146a rs2910164 and gastric cancer (GC) risk, but results have been inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. PubMed and China National Knowledge Infrastructure searches were carried out for relevant studies published before July 2014.