(HealthDay News) — A new open-source platform can accelerate the matching of cancer patients to precision medicine (PM) oncology trials, according to a study published in npj Precision Oncology.

Harry Klein, PhD, from Dana-Farber Cancer Institute in Boston, and colleagues developed MatchMiner, a platform designed to computationally match genomically profiled cancer patients to PM trials.

MatchMiner has 3 modes of use. With the patient-centric mode, clinicians look up a patient to view all trials that are a match for that patient. With the trial-centric mode, clinical trial teams identify patients for PM trials. With trial search, clinicians manually enter search criteria to identify available trials based on external genomic reports.


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From March 2016 through March 2021, Dr Klein and colleagues curated 354 PM trials with a broad range of genomic and clinical eligibility criteria, and MatchMiner facilitated 166 trial consents for 159 patients. Patients matched to trials via MatchMiner had a shorter time from the genomic sequencing report date to trial consent (55 days shorter; 22% earlier) than patients consented through non-MatchMiner means.

“With three modes of use, MatchMiner can be used to look up trials for individual patients or to recruit patients for a trial,” the researchers wrote. “MatchMiner can be used with a trial management system to show real-time trial status at the arm level. The combination of real-time trial arm status with detailed genomic eligibility down to the variant level allows MatchMiner to provide highly specific matches to PM trials.”

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