Similar to most oncology data, future studies are needed to evaluate the effects of sildenafil and other PDE5 inhibitors on different forms of cancer within human patients — not just in animal and cell line models. There are multiple clinical trials currently enrolling patients to evaluate the effects of sildenafil on a multitude of cancers including pancreatic, brain, myelodysplastic syndrome, multiple myeloma, head and neck, and other solid tumors.2 There are also studies evaluating the effect of PDE5 inhibitors in modulating the toxicity of certain chemotherapeutic agents such as doxorubicin, which is another unique application for this class of medications. 


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