Patients with metastatic epidural spinal cord compression (MESCC) can choose to have surgical intervention as an adjunct to radiation and chemotherapy, as it improves health-related quality of life, according to a study published online ahead of print in the Journal of Clinical Oncology.1
In this study, researchers sought to evaluate survival, neurologic, functional, and health-related quality of life outcomes in patients with MESCC who underwent surgery management.
A total of 140 patients with a single symptomatic MESCC lesion were enrolled in the study. Investigators collected clinical data preoperatively and at 3, 6, 9, and 12 months postoperatively.
Examples of data collected include results from the Brief Pain Inventory, the American Spinal Injury Association Impairment scale, SF-36 Short Form Health Survey, Oswestry Disability Index, and EurQol 5 dimensions.
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Results showed that 30-day and 12-month mortality rates were 9% and 62%, respectively. Ambulatory status and lower extremity and total motor scores were improved at 6 months postoperatively. The Oswestry Disability Index improved at 6 weeks, and at 3, 6, and 12 months.
In regard to safety, wound complications occurred in 10% of patients and 2 required a second surgery.
- Fehlings MG, Nater A, Tetreault L, et al. Survival and clinical outcome in surgically treated patients with metastatic epidural spinal cord compression: results of the prospective multicenter AOSpine study [published online ahead of print November 23, 2015]. J Clin Oncol. doi: 10.1200/JCO.2015.61.9338.