A study published in JAMA Oncology showed, interestingly, that the benefits of vitamin D3 supplementation for the prevention of advanced colorectal adenomas may vary according to vitamin D receptor genotype.5 The study of about 1700 people showed that the effect of vitamin D3 supplementation on advanced adenomas varied according to genotype at 2 vitamin D receptor SNPs: supplementation reduced risk among patients with rs7968585 with the AA genotype, though it increased risk among patients with 1 or 2 G alleles.

The researchers said that these results are a “first step” toward identifying which individuals may benefit or be harmed by vitamin D interventions, reflecting the variety of results from studies of supplementation in recent years.

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According to the National Cancer Institute, there are not enough available data to establish whether taking vitamin D can prevent cancer.6 New randomized trials will need to be conducted to more fully understand the effect of vitamin D on cancer and its outcomes.

RELATED: Vitamin D Deficiency Linked to Bladder Cancer

Among those studies in progress are the Vitamin D/Calcium Polyp Prevention Study (ClinicalTrials.gov Identifier: NCT00153816), which is examining whether vitamin D supplementation given alone or with calcium prevents the development of colorectal adenomas in patients with previous adenoma removal, and the VITAL trial (ClinicalTrials.gov Identifier: NCT01169259), which is evaluating whether vitamin D supplements can prevent a variety of cancers in older men and women. 


  1. Nyame YA, Murphy AB, Bowen DK, et al. Associations between serum vitamin D and adverse pathology in men undergoing radical prostatectomy. J Clin Oncol. 2016;34(12):1345-9.
  2. Low vitamin D levels linked to increased risk of bladder cancer. University of Warwick website. http://www2.warwick.ac.uk/newsandevents/news/low_vitamin_d/. Published November 8, 2016. Accessed December 19, 2016.
  3. McDonnell SL, Baggerly C, French CB, et al. Serum 25-hydroxyvitamin D concentrations >=40 ng/mL associated with a >65% lower cancer risk: pooled analysis of randomized trial and prospective cohort study. PLoS One. 2016;11(4):e0152441.
  4. Yao S, Kwan ML, Ergas IJ, et al. Association of serum level of vitamin D at diagnosis with breast cancer survival: a case-cohort analysis in the pathways study. JAMA Oncol. 2016 Nov 10. doi: 10.1001/jamaoncol.2016.4188 [Epub ahead of print]
  5. Barry EL, Peacock JL, Rees JR, et al. Vitamin D receptor genotype, vitamin D3 supplementation, and risk of colorectal adenomas: a randomized clinical trial. JAMA Oncol. 2016 Dec 15. doi: 10.1001/jamaoncol.2016.5917 [Epub ahead of print]
  6. Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2011;155(12):827-38.