This study aims to determine whether any tumor biomarkers could account for the survival advantage observed in the LNH 03–2B trial among patients with diffuse large B–cell lymphoma (DLBCL) and low–intermediate risk according to the International Prognostic Index when treated with dose–intensive rituximab, doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone (R–ACVBP) compared with standard rituximab, doxorubicin, cyclophosphamide, vincristine, and prednisone (R–CHOP).

The survival benefit related to R–ACVBP over R–CHOP is at least partly linked to improved survival among patients with non–GCB DLBCL.

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