(ChemotherapyAdvisor) – Late age at last birth is independently associated with a long-term reduced risk of endometrial cancer, according to a team of researchers of the University of Southern California, Los Angeles, CA. “Age at Last Birth in Relation to Risk of Endometrial Cancer: Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium,” which was published online in the American Journal of Epidemiology.
According to the authors of this study, previous studies have demonstrated that childbearing at an older age is associated with a lower risk of endometrial cancer. The authors sought to determine whether the association is independent of the number of births or other factors. The investigators pooled individual-level data from 4 cohort and 13 case-control studies in the Epidemiology of Endometrial Cancer Consortium, totaling 8,671 cases of endometrial cancer and 16,562 controls.
The investigators reported that, after adjustment for known risk factors, endometrial cancer risk declined with increasing age at last birth (Ptrend<0.0001). “The pooled odds ratio per 5-year increase in age at last birth was 0.87 (95% confidence interval: 0.85–0.90),” they reported. “Women who last gave birth at 40 years of age or older had a 44% decreased risk compared with women who had their last birth under the age of 25 years (95% confidence interval: 47–66).” More importantly, the investigators observed that this protective association was similar across the different age-at-diagnosis groups and for the 2 major tumor histologic subtypes (type I and type II).
The investigators concluded that late age at last birth is independently associated with a long-term reduced risk of endometrial cancer.