Diabetes mellitus (DM) was determined to be an independent unfavorable prognostic factor in Asian patients with early cervical cancer (CC), according to an article published online in the journal The Oncologist.
In this study, 2,946 patients diagnosed with primary stage 2-2A CC and received curative treatments between 2004 and 2008 were identified from the nationwide Taiwan Cancer Registry database. In total, 284 (9.6%) patients had DM.
Results showed patients with DM had significantly lower 5-year cervical cancer-specific survival (CSS) and overall survival (OS) rates compared to patients without DM (CSS: 85.4% vs. 91.5%; OS: 73.9% vs. 87.9%, respectively).
The investigators found that DM remained an independent unfavorable prognostic factor for CSS (aHR, 1.46) and OS (aHR, 1.55), after adjusting for clinicopathologic variables and comorbidities.
The study’s findings indicated that the risk of cancer recurrence and death in patients with early stage CC may be increased by DM, even after receiving curative treatments.
Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsinchu, Taiwan, Republic of China; Departments of Oncology, Internal Medicine, and Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan, Republic of China; Graduate Institute of Oncology, College of Medicine, and Institute of Epidemiology and Preventive Medicine, College of Public