Certain STIs May Play a Role in Ovarian Cancer Development
C. trachomatis and herpes simplex virus-2 were both linked to epithelial ovarian cancer.
Gynecologic, Ovarian, and Cervical Cancer News
GYNECOLOGIC CANCER ADVISOR
Clinical Utility of Deep Phenotyping and Whole Genome Risk Assessment in Early Cancer Detection and Precision Oncology
State-of-the-art advanced imaging coupled with whole-genome sequencing shows utility in early cancer detection and cancer-associated pathogenic variant detection.
Postsurgical Mutations Detected in Cell-Free DNA in Endometrial Cancer May Indicate Poor Prognosis
In this study, pre- and postsurgical specimens of cell-free DNA from women with newly diagnosed endometrial cancer were subjected to ultra-high depth sequencing.
Potential Predictors of Cell Transformation in Normal Fallopian Tubes of Women With a Deleterious BRCA1 Mutation
The search for molecular precursors of cancer in the fallopian tubes is largely driven by emerging evidence supporting it as the site of origin for many ovarian cancers.
Real-World Data Show Low Rates of Somatic BRCA Mutation Testing in Ovarian Cancer
This study evaluated the rates of germline and somatic BRCA testing in women with ovarian cancer included in the Flatiron Health database.
Further Refining Which Subgroups of Patients With Ovarian Cancer Benefit Most From Addition of Olaparib to Maintenance Therapy With Bevacizumab
PAOLA-1/ENGOT-ov25 is a phase 3 clinical trial evaluating a first-line olaparib plus bevacizumab maintenance regimen in patients with advanced ovarian cancer.
More Evidence Supporting the Clinical Benefit of Niraparib Maintenance Therapy After Chemo in Advanced Ovarian Cancer
This analysis presents preliminary data for secondary endpoints of TFST and PFS2 from the phase 3 PRIMA/ENGOTOV26/GOG-3012 study.
Phase 3 Trial Examining ICIs in Epithelial Ovarian Cancers Halted Due to Futility
JAVELIN Ovarian 100 was the first phase 3 study to evaluate an immune checkpoint inhibitor in previously untreated advanced epithelial ovarian cancer.
No OS Benefit for Addition of Metformin to Platinum-Based Therapy in Advanced Endometrial Cancer
The insulin-lowering properties of metformin, along with its effects on synthetic metabolism, were some of the rationales for its use as a cancer therapy.
Lenvatinib-Pembrolizumab Improves Outcomes in Recurrent Endometrial Cancer: KEYNOTE-146/Study 111
Lenvatinib plus pembrolizumab demonstrated promising antitumor efficacy against recurrent endometrial cancer, which led to its FDA approval.
Copper Intrauterine Devices Tied to Lower Risk for Cervical Cancer
Findings based on comparison to hormonal intrauterine devices.
Higher Risk of Ovarian Clear Cell Cancer in Asian Pacific Islanders
Regardless of birthplace, women who are Asian Pacific Islanders appear to have a higher risk of developing ovarian clear cell cancer compared with other ethnicities.
CMS Covers Next-Generation Sequencing for Breast and Ovarian Cancer
CMS recently announced that patients with germline ovarian or breast cancer would be covered for diagnostic testing that uses next-generation sequencing.
ASCO Guideline: Germline Testing Recommended for All Women Diagnosed With Epithelial Ovarian Cancer
A pervading theme of this guideline was the importance of including genetic counselors in the interpretation and communication of germline and somatic testing results.
Whether HPV Vaccination Will Prevent Cervical Cancer Unclear
Review highlights limitations of trial design; additional research needed to address uncertainties.
Preclinical Work on Red Blood Cell-Based Therapies in HPV-Positive Solid Tumors Provides Rationale for Clinical Trials in Humans
A microfluidics platform for engineering activated antigen carrier immunotherapies from red blood cells showed promising preliminary results in a mouse model.
Bevacizumab Adoption Tied to Use by Peers
The decision to adopt bevacizumab could be appraised by the prior level of uptake among their peers in their medical community.
New Research Says There’s No Significant Link Between Talc and Ovarian Cancer, but Some Scientists Push Back Against the Study’s Data and Design
Some experts say the talc study’s data limitations weaken its impact in the field.
Fertility-Sparing Surgery Achieves Good Oncologic, Obstetric Outcomes in Younger Women With Early-Stage Nonepithelial Ovarian Cancer
In this first reported prospective study, researchers compared outcomes of fertility-sparing surgery with radical surgery in women with stage I nonepithelial ovarian cancer.
PALB2 Linked to Increased Risk for Breast, Ovarian, and Pancreatic Cancer
Germline PALB2 pathogenic variants were associated with an increased risk of female or male breast cancer, as well as ovarian and pancreatic cancer.
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