Combination Anlotinib and Sintilimab Exhibits Antitumor Activity in Advanced Endometrial Cancer
Nearly three-quarters of patients responded to treatment.
Gynecologic, Ovarian, and Cervical Cancer News
GYNECOLOGIC CANCER ADVISOR
Universal Genetic Testing Is Far From a Reality in Patients With Ovarian Cancer
A new review points to low rates of genetic testing in patients with ovarian cancer.
Injection May Illuminate Hard-to-Spot Ovarian Cancer Lesions for Surgical Resection
One-third of patients had an additional lesion removed with use of pafolacianine sodium.
Mirvetuximab Soravtansine Plus Bevacizumab Looks Promising in Platinum-Agnostic Ovarian Cancer
The combination produced durable responses in patients with high folate receptor alpha expression.
Adjuvant Chemotherapy ‘Should Not Be Used’ After Chemoradiation in Locally Advanced Cervical Cancer
The 5-year overall survival rate was not improved by adjuvant chemotherapy.
Secondary Cytoreduction Improves Progression-Free Survival in Platinum-Sensitive, Relapsed Ovarian Cancer
The median progression-free survival was nearly 6 months longer in patients who underwent surgery.
Lack of Standardized Screening Linked to Increased Incidence of Many HPV-Related Cancers
For HPV-related cancers without standardized screening, incidence rates increased between 2001 and 2017.
Tisotumab Vedotin: A Novel Treatment for Recurrent or Metastatic Cervical Cancer
Tisotumab vedotin is an investigational antibody-drug conjugate directed against tissue factor.
Maintenance Therapy With Olaparib Improves Survival in Relapsed Ovarian Cancer
Investigators performed a final analysis of SOLO2 to investigate the effect of olaparib on overall survival in patients with ovarian cancer and a BRCA1/2 mutation.
PARP Inhibitor Maintenance Improves PFS in Patients with Platinum-Sensitive, Recurrent Ovarian Cancer
Maintenance with a PARP inhibitor benefited all subsets of patients
Lynch Syndrome, Recurrence-Free Survival in Endometrial Cancer
There was a trend of different 5-year RFS among the groups, with the shortest among patients with MLH1-hypermethylated disease at 78.6% compared with 95.5% among patients with other causes of MMRd.
Adjuvant Therapy Benefit Questioned in POLE-Mutated Endometrial Cancer
The study researchers reported that endometrial cancers with these somatic mutations have unfavorable pathologic features.
Peritoneal Cytology Prognostic in Stage II-III Endometrial Cancer
Researchers found that the benefit of adjuvant therapy differed depending on the status of peritoneal cytology in women with endometrial cancer.
Intrauterine Levonorgestrel Showed Activity in Endometrial Adenocarcinoma
Researchers sought to determine if LNG-IUD is effective and whether the addition of weight loss or metformin can further improve response in patients with EAC and EHA.
Study Reports Improved Outcomes With Olaparib Maintenance in Ovarian Cancer
A team of investigators conducted a double-blind, placebo-controlled, phase 3 trial to assess outcomes following olaparib treatment in patients with BRCA 1/2-mutated, relapsed ovarian cancer.
Tisotumab Vedotin Under Review for Recurrent or Metastatic Cervical Cancer
Tisotumab vedotin is an investigational antibody-drug conjugate targeted to tissue factor.
Improved Overall Survival With Cemiplimab in Cervical Cancer Trial
The phase 3 trial evaluated the efficacy and safety of cemiplimab in women 18 years of age and older with recurrent or metastatic cervical cancer, including those with either squamous cell carcinoma or adenocarcinoma.
Most Patients With Breast, Ovarian Cancer Do Not Undergo Genetic Testing
The number of genes tested for ovarian and breast cancer has grown, but most patients do not undergo testing, and variant-of-unknown-significance results are common, especially among minority populations.
Adjuvant Sequential Chemoradiation Affords Superior DFS Benefit Versus CCRT, RT in Early-Stage Cervical Cancer
Investigators evaluated the clinical benefits of sequential chemoradiation (SCRT), concurrent chemoradiation (CCRT), and radiation alone (RT) as postoperative adjuvant treatments in early-stage cervical cancer.
Report Documents Cancer Transmission From Mother to Infant
The cases were incidentally identified during a next-generation sequencing (NGS) analysis of matched normal and tumor tissue for a hospital-based prospective study.
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