Researchers from the Danbury Hospital Biomedical Research Institute have discovered that high expression levels of two proteins — HGF and c-MET — are present in women with ovarian cancer who did not benefit from undergoing tumor-shrinking chemotherapy therapy prior to having surgery to remove their tumor.

Marisa Mariani, PhD, of Danbury Hospital Biomedical Research Institute, and colleagues, who published their results in OncoTarget, made this discovery using a two-pronged approach that first explored possible markers of chemotherapy resistance at the microRNA and gene expression level, and then validated any markers of interest at the protein level.

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