(HealthDay News) — There is no association between soy intake and endometrial cancer risk, according to a study published online in BJOG: An International Journal of Obstetrics & Gynaecology.

S. Budhathoki, from the National Cancer Center in Japan, and colleagues evaluated soy intake measured in a food frequency questionnaire (1995 to 1998) among 49,121 women (aged 45 to 74 years) also participating in a 5-year follow-up survey questionnaire.

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The researchers found that over an average of 12.1 years of follow up, there were 112 newly diagnosed endometrial cancer cases. There was no association between energy-adjusted intakes of soy food and isoflavone and the risk of endometrial cancer.

For each 25 grams per day increase in the intake of soy food, the multivariate-adjusted hazard ratio was 1.02 (95% CI, 0.94 to 1.10), and the corresponding value for isoflavone intake per 15 mg per day was 1.01 (95% CI, 0.84 to 1.22).

“In this population-based prospective cohort study of Japanese women, we observed no evidence of a protective association between soy food or isoflavone intake and endometrial cancer risk,” the researchers wrote.


  1. Budhathoki S, Iwasaki M, Sawada N et al. Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study. BJOG. 2014;doi:10.1111/1471-0528.12853.