This research compared the long–term outcomes between LA–NPC patients treated with neoadjuvant chemotherapy followed by radiotherapy (NACT) and those treated with concurrent chemoradiotherapy (CCRT). For LA–NPC, both CCRT and NACT were similarly efficacious treatment strategies in terms of long–term disease control and survival probability.

Close locoregional follow–up is recommended for patients receiving NACT, because these patients are more prone to develop locoregional failure than patients receiving CCRT.

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