Immunological Profiling of High-Grade Gliomas Reveals Subtypes That Influence Survival
Four distinct immunologic groups independent of patient age were identified and correlated with overall survival in patients with high-grade glioma.
Head and Neck Cancer News
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Head and Neck Cancer News
Following NCCN Surveillance Guidelines in Oropharyngeal Carcinoma Did Not Yield a Survival Benefit: Study
Patients with HPV–associated oropharyngeal squamous cell carcinoma who adhered to the NCCN clinical surveillance recommendations did have improved survival.
Minority, Low-Income Individuals Less Likely to Receive Oral Cancer Screening
Education level, insurance type also may affect likelihood of oral cancer screening at dental visit.
Rozlytrek, a Tumor Agnostic Therapy, Receives FDA Approval
The Food and Drug Administration (FDA) has granted accelerated approval to Rozlytrek (entrectinib; Genentech).
Treatment Reduction in Intermediate-Risk Neuroblastoma Deemed Successful
For specific subsets of patients with intermediate-risk neuroblastoma, an algorithm successfully reduced treatment while maintaining survival outcomes.
Incidence of HPV-Positive OPSCC Is Double That Seen in HPV-Negative Disease
Incidence was greatest among white men aged 60 to 64 years.
Post-Op Radiation Safely Eliminated in Node-Negative Neck HNSCC
Elimination of radiation therapy did not alter quality-of-life outcomes.
Age Does Not Impact Survival After Transthoracic Esophagectomy, Study Finds
Age was not a significant prognostic factor for long-term survival after transthoracic esophagectomy among patients with thoracic esophageal cancer.
Statins May Be Beneficial After Radiation to Thorax, Head, Neck
Statin use tied to reduction in stroke incidence for cardiac patients with thorax and head or neck cancer.
Keytruda Approved for First Line Treatment of Unresectable, Recurrent HNSCC
The FDA has approved Keytruda (pembrolizumab; Merck) for first line treatment of patients with metastatic or unresectable, recurrent head and neck squamous cell carcinoma as monotherapy for patients whose tumors express PD-L1 (Combined Positive Score [CPS] ≥1) or in combination with platinum and fluorouracil (FU) regardless of PD-L1 expression.
Mouth Rinse for HPV DNA May Be Biomarker in Head, Neck Cancer
Human papillomavirus (HPV) DNA detected from a mouth rinse may be an effective marker for prognosis during treatment of HPV-positive head and neck cancer
Entrectinib Shows Activity in Pediatric Brain Tumors and Other Solid Tumors
Entrectinib showed activity and appeared to be safe in pediatric patients with recurrent or refractory solid tumors harboring NTRK1/2/3, ROS1, or ALK aberrations.
High Circulating Levels of Cytomegalovirus DNA Linked to Poor OS in Head and Neck Cancer
Evidence is provided for an association between CMV reactivation and poor OS of patients with head and neck cancer in the setting of high systemic inflammation.
Delivery of Alternating Electrical Fields Increases Cell Membrane Permeability in Glioblastoma Multiforme
The researchers speculated that the delivery of alternating electric fields to GBM cells may facilitate the delivery of chemotherapy.
Contrast-Enhanced MRI Characterization of Brain Cancers
According to researchers, neovascularization is more common in glioblastoma, and extravasation is more common in primary CNS lymphoma.
Gene Signature Predicts Outcomes in HPV-Related Oropharyngeal Cancers
HPV gene signature was associated with outcomes in patients with HPV-related oropharyngeal cancers and could become a prognostic biomarker.
Consequences of HPV-Related Disparities in Head and Neck Cancer
A review article highlighted the racial disparities in head and neck cancer incidence and identified how this relates to HPV infection.
Hybrid Minimally Invasive Esophagectomy Confers Lower Complication Rate
Patients who had hybrid minimally invasive esophagectomy had a lower rate of surgery-related complications than those who had transthoracic open esophagectomy.
Liquid Biopsy of Cerebrospinal Fluid Provides Genomic Info on Brain Tumors
Clinical application of cerebrospinal fluid ctDNA analysis remains unclear.
ASCO Critiques Guideline for HPV Testing in Head and Neck Cancer
ASCO reviewed and critiqued the College of American Pathologists guideline for human papillomavirus testing in head and neck cancer.
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