No Correlation Between SF3B1 Mutation in Myelodysplastic Syndrome and Overall Survival
Researchers evaluated 15 studies in patients with myelodysplastic syndrome to determine the prognostic value of mutations in the SF3B1 gene.
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Hematologic Cancers News
Checklist Ensures Adherence to Recommended CAR-T Cell Administration Processes
How one facility ensures compliance with a complex treatment protocol.
Nanatinostat Gets Orphan Drug Designation for EBV-Associated Cancers
The “Kick & Kill” platform is designed to treat viral-associated cancers and other serious diseases.
Presence of Autoimmune Diseases May Increase Risk for Diffuse Large B Cell, Marginal Zone Lymphomas
The presence of rheumatologic conditions was also associated with variations in cancer site for both diffuse large B-cell lymphoma and marginal zone lymphoma.
Support for Multimodality Therapy in Some Patients With Follicular Lymphoma
Follicular lymphoma is classified into 3 histologic grades on the basis of the number of centroblasts per high-power field.
A Case of Intra-Abdominal Follicular Lymphoma Presenting as Heart Failure
Results of epidemiologic studies suggest that exposure to Agent Orange may be associated with an increased risk of non-Hodgkin lymphoma.
Standardization of Minimal Residual Disease Measurements in Philadelphia-Positive ALL
Variability in minimal residual disease measurement techniques inhibits the ability to compare data across laboratories and clinical trials.
Improved Long-Term Outcomes After Stronger Postinduction Intensification for Acute Lymphoblastic Leukemia
Patients with rapid early response demonstrated increased event-free and overall survival when receiving augmented postinduction intensification regimens.
Cytogenetic Abnormalities Provide Prognostic Value in Predicting Acute Myeloid Leukemia Outcomes
Patients with a monosomal or complex karyotype were found to have lower rates of leukemia-free survival compared with patients with a normal karyotype.
Consensus Panel on Maintenance Therapies Following Autologous Hematopoietic Cell Transplantation in Lymphoma
An expert panel reviewed current literature surrounding lymphoma treatment to identify and address any gaps in knowledge.
Antibiotic Discontinuation in Neutropenic Patients With Acute Myeloid Leukemia
Discontinuing antibacterial therapy in neutropenic patients with acute myeloid leukemia did not lead to excessive mortality or severe infections.
Novel Toxicities, Anticancer Activity of Anti-CD22 CAR-T Therapies Revealed
Hemophagocytic lymphohistiocytosis is a rare, but potentially fatal, complication of immunotherapy, resulting from immune hyperactivation.
An Integrated Analysis for Selecting Ibrutinib-Based Combination Therapy in CLL
An integrated assessment of the results from 2 assays showed promise for tailoring ibrutinib-based targeted therapy in patients with CLL.
Changes in Hematologic Parameters Following Pesticide Exposure
Researchers found that permethrin application was associated with changes in hematologic parameters that persisted for a least 3 weeks.
Two Measures Independently Predict for NHL in Patients With HIV
Both a high HIV viral load and a low CD4 level independently predict for the risk of NHL in patients who have HIV.
Contrast-Enhanced MRI Characterization of Brain Cancers
According to researchers, neovascularization is more common in glioblastoma, and extravasation is more common in primary CNS lymphoma.
Poor Outcome for Patients With Multiple Myeloma Who Are Refractory to CD38-Targeting Agent
Subgroup analyses of outcomes following development of disease refractory to a CD38-targeting agent suggested that carfilzomib + an alkylator have some efficacy.
Marginal Zone Lymphoma Presentation at Multiple Mucosal Sites May Be Linked to Poorer Outcomes
Poor prognostic factors for patients with EMZL include age greater than 70 years, advanced Ann Arbor stage, and elevated lactate dehydrogenase (LDH)
Managing Neutropenic Sepsis in Patients With Cancer
Septic shock is a leading cause of death in chemotherapy-treated patients with neutropenia, and updated guidelines for managing sepsis in this setting were recently published in Annals of Hematology.
Molecular Characterization of Pediatric Follicular Lymphoma
Pediatric follicular lymphomas involve interactions in MAPK and G-protein protein receptor signaling pathways, according to new research.
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