Higher graft CD8 dose predicted better survival in patients undergoing reduced-intensity conditioned (RIC) allogenic hematopoietic stem-cell transplantation (alloHSCT) in adults with hematologic malignancies, a new study published online ahead of print in the Journal of Clinical Oncology has shown.

For the study, researchers evaluated associations between graft T-cell doses and outcomes in 200 patients who underwent RIC alloHSCT with a peripheral blood stem-cell graft.

Results showed that higher CD8 cell doses were associated with a reduced risk for relapse (aHR = 0.43; P=0.009), improved relapse-free survival (aHR = 0.50; P=0.006), and improved overall survival (aHR = 0.57; P = 0.04). Researchers found no significant increase in graft-versus-host disease or nonrelapse mortality.

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The study also demonstrated that donor age was inversely associated with graft CD8 dose, meaning younger donors were more likely to provide a higher CD8 cell dose graft.

Researchers were able to predict graft CD8 content by measuring the proportion of CD8 cells in a screening blood sample from donors.


  1. Reshef R, Huffman AP, Gao A, et al. High graft CD8 cell dose predicts improved survival and enables better donor selection in allogenic stem-cell transplantation with reduced-intensity conditioning. J Clin Oncol. 2015. [Epub ahead of print]. doi: 10.1200/JCO.2014.60.1203.